Three decades of amyloid beta synthesis: Challenges and advances

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dc.contributor.author Kasim, Johanes en
dc.contributor.author Kavianinia, Iman en
dc.contributor.author Harris, Paul en
dc.contributor.author Brimble, Margaret en
dc.date.accessioned 2019-10-02T00:09:44Z en
dc.date.issued 2019-07 en
dc.identifier.citation Frontiers in Chemistry 7:25 pages Article number 472 Jul 2019 en
dc.identifier.issn 2296-2646 en
dc.identifier.uri http://hdl.handle.net/2292/48320 en
dc.description.abstract Aggregation of the pathological amyloid beta (Aβ) isoform Aβ1−42 into senile plaques is a neuropathological hallmark of Alzheimer's disease (AD). The biochemical significance of this phenomenon therefore necessitates the need for ready access to Aβ1−42 for research purposes. Chemical synthesis of the peptide, however, is technically difficult to perform given its propensity to aggregate both on resin during solid phase peptide synthesis and in solution during characterization. This review presents a chronological summary of key publications in the field of Aβ1−42 synthesis, dating back from its maiden synthesis by Burdick et al. Challenges associated with the preparation of Aβ1−42 were identified, and the solutions designed over the course of time critically discussed herein. Ultimately, the intention of this review is to provide readers with an insight into the progress that has been made in the last three decades, and how this has advanced broader research in AD. en
dc.language English en
dc.publisher Frontiers Media S.A. en
dc.relation.ispartofseries Frontiers in Chemistry en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://www.frontiersin.org/journals/chemistry#author-guidelines en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Science & Technology en
dc.subject Physical Sciences en
dc.subject Chemistry, Multidisciplinary en
dc.subject Chemistry en
dc.subject Alzheimer's disease en
dc.subject dementia en
dc.subject neurodegenerative disorders en
dc.subject difficult peptide sequences en
dc.subject amyloid beta en
dc.subject peptide chemistry en
dc.subject solid phase peptide synthesis en
dc.subject SOLID-PHASE SYNTHESIS en
dc.subject ALZHEIMERS-DISEASE en
dc.subject PEPTIDE-SYNTHESIS en
dc.subject PROTEIN en
dc.subject PURIFICATION en
dc.subject AGGREGATION en
dc.title Three decades of amyloid beta synthesis: Challenges and advances en
dc.type Journal Article en
dc.identifier.doi 10.3389/fchem.2019.00472 en
pubs.volume 7 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Review en
pubs.elements-id 776623 en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.number 472 en
pubs.record-created-at-source-date 2019-10-09 en


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