Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery.

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dc.contributor.author Kanamala, Manju en
dc.contributor.author Palmer, Brian en
dc.contributor.author Jamieson, Stephen en
dc.contributor.author Wilson, William R en
dc.contributor.author Wu, Zimei en
dc.date.accessioned 2019-10-02T00:15:46Z en
dc.date.issued 2019-08 en
dc.identifier.citation Nanomedicine (London, England) 14(15):1971-1989 Aug 2019 en
dc.identifier.issn 1743-5889 en
dc.identifier.uri http://hdl.handle.net/2292/48322 en
dc.description.abstract Aim: pH-sensitive liposomes (pSL) have emerged as promising nanocarriers due to their endo/lysosome-escape abilities, however, their pH sensitivity is compromised by poly(ethylene glycol) (PEG) coating. This study investigates whether an intracellular PEG-detachment strategy can overcome this PEG dilemma. Materials & methods: First, PEG2000 was conjugated with a phospholipid via an acid-labile hydrazide-hydrazone bond (-CO-NH-N = CH-), which was postinserted into pSL, forming PEG-cleavable pSL (CL-PEG-pSL). Their endo/lysosomal-escape abilities in MIA PaCa-2 cells, pharmacokinetics and tumor accumulation abilities were studied using PEG-pSL as reference. Results: CL-PEG-pSL showed rapid endo/lysosome-escape abilities in the cancer cells and higher tumor accumulation in MIA PaCa-2 xenograft model in contrast to PEG-pSL. Conclusion: Cleavable PEGylation is an efficient strategy to ameliorate the PEG dilemma of pSL for cancer drug delivery. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Nanomedicine (London, England) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by-nd/4.0/ en
dc.rights.uri https://www.futuremedicine.com/authorguide/archivesharearticle en
dc.subject Cell Line, Tumor en
dc.subject Animals en
dc.subject Humans en
dc.subject Mice, Nude en
dc.subject Rats, Sprague-Dawley en
dc.subject Neoplasms en
dc.subject Polyethylene Glycols en
dc.subject Doxorubicin en
dc.subject Deoxycytidine en
dc.subject Antineoplastic Agents en
dc.subject Liposomes en
dc.subject Delayed-Action Preparations en
dc.subject Drug Delivery Systems en
dc.subject Hydrogen-Ion Concentration en
dc.title Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery. en
dc.type Journal Article en
dc.identifier.doi 10.2217/nnm-2018-0510 en
pubs.issue 15 en
pubs.begin-page 1971 en
pubs.volume 14 en
dc.rights.holder Copyright: The authors en
pubs.end-page 1989 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 779625 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Pharmacology en
pubs.org-id Pharmacy en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1748-6963 en
pubs.record-created-at-source-date 2019-07-30 en
pubs.dimensions-id 31355712 en

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