dc.contributor.author |
Kanamala, Manju |
en |
dc.contributor.author |
Palmer, Brian |
en |
dc.contributor.author |
Jamieson, Stephen |
en |
dc.contributor.author |
Wilson, William R |
en |
dc.contributor.author |
Wu, Zimei |
en |
dc.date.accessioned |
2019-10-02T00:15:46Z |
en |
dc.date.issued |
2019-08 |
en |
dc.identifier.citation |
Nanomedicine (London, England) 14(15):1971-1989 Aug 2019 |
en |
dc.identifier.issn |
1743-5889 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/48322 |
en |
dc.description.abstract |
Aim: pH-sensitive liposomes (pSL) have emerged as promising nanocarriers due to their endo/lysosome-escape abilities, however, their pH sensitivity is compromised by poly(ethylene glycol) (PEG) coating. This study investigates whether an intracellular PEG-detachment strategy can overcome this PEG dilemma. Materials & methods: First, PEG2000 was conjugated with a phospholipid via an acid-labile hydrazide-hydrazone bond (-CO-NH-N = CH-), which was postinserted into pSL, forming PEG-cleavable pSL (CL-PEG-pSL). Their endo/lysosomal-escape abilities in MIA PaCa-2 cells, pharmacokinetics and tumor accumulation abilities were studied using PEG-pSL as reference. Results: CL-PEG-pSL showed rapid endo/lysosome-escape abilities in the cancer cells and higher tumor accumulation in MIA PaCa-2 xenograft model in contrast to PEG-pSL. Conclusion: Cleavable PEGylation is an efficient strategy to ameliorate the PEG dilemma of pSL for cancer drug delivery. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Nanomedicine (London, England) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by-nd/4.0/ |
en |
dc.rights.uri |
https://www.futuremedicine.com/authorguide/archivesharearticle |
en |
dc.subject |
Cell Line, Tumor |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Mice, Nude |
en |
dc.subject |
Rats, Sprague-Dawley |
en |
dc.subject |
Neoplasms |
en |
dc.subject |
Polyethylene Glycols |
en |
dc.subject |
Doxorubicin |
en |
dc.subject |
Deoxycytidine |
en |
dc.subject |
Antineoplastic Agents |
en |
dc.subject |
Liposomes |
en |
dc.subject |
Delayed-Action Preparations |
en |
dc.subject |
Drug Delivery Systems |
en |
dc.subject |
Hydrogen-Ion Concentration |
en |
dc.title |
Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.2217/nnm-2018-0510 |
en |
pubs.issue |
15 |
en |
pubs.begin-page |
1971 |
en |
pubs.volume |
14 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.end-page |
1989 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
779625 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
Pharmacy |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1748-6963 |
en |
pubs.record-created-at-source-date |
2019-07-30 |
en |
pubs.dimensions-id |
31355712 |
en |