Circulatory miRNA biomarkers of metabolic syndrome.

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dc.contributor.author Ramzan, Farha en
dc.contributor.author D'Souza, RF en
dc.contributor.author Durainayagam, BR en
dc.contributor.author Milan, Amber en
dc.contributor.author Markworth, JF en
dc.contributor.author Miranda-Soberanis, V en
dc.contributor.author Sequeira, Ivana en
dc.contributor.author Roy, NC en
dc.contributor.author Poppitt, Sally en
dc.contributor.author Mitchell, Cameron en
dc.contributor.author Cameron-Smith, David en
dc.date.accessioned 2019-10-02T00:59:16Z en
dc.date.issued 2019-08-21 en
dc.identifier.issn 0940-5429 en
dc.identifier.uri http://hdl.handle.net/2292/48351 en
dc.description.abstract AIMS:Circulatory microRNAs (c-miRNAs) exert important roles in the molecular dysregulation of cardio-metabolic diseases. However, little is known whether dysregulated miRNA expression occurs when risk factors are elevated, as in the metabolic syndrome (MetS). This study quantified c-miRNA expression in individuals with MetS compared to healthy, further examining the relationship of gene pathways with the underlying pathogenesis. METHODS:Expression of 26 miRNAs was quantified in plasma from 40 women (20 healthy and 20 MetS) and 39 men (20 healthy and 19 MetS) by qPCR. In silico analysis was performed to investigate biological effects of the dysregulated miRNAs. Dysregulated miRNA expression was further validated in an independent cohort of 20 women (10 healthy and 10 MetS). RESULTS:Regression model adjusted for age and sex identified miR-15a-5p, miR-17-5p, miR-370-3p and miR-375 as important predictors of MetS presence. Analysis of predictive miRNAs in the validation cohort strengthened the relationship with miR-15a-5p and miR-17-5p expression. These miRNAs share genes involved in the regulation of metabolic pathways including insulin, wnt, fatty acid metabolism and AMPK. CONCLUSIONS:miR-15a-5p and miR-17-5p were identified as predictive biomarkers of MetS, irrespective of sexes, further demonstrating the relationship of c-miRNAs to known pathways of metabolic disturbances present in cardio-metabolic diseases. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Acta diabetologica en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Circulatory miRNA biomarkers of metabolic syndrome. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s00592-019-01406-6 en
dc.rights.holder Copyright: The author en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 779758 en
pubs.org-id Liggins Institute en
pubs.org-id Science en
pubs.org-id Biological Sciences en
dc.identifier.eissn 1432-5233 en
pubs.record-created-at-source-date 2019-08-23 en
pubs.dimensions-id 31435783 en


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