The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

Chepanova, Arina A; Mozhaitsev, Evgenii S; Munkuev, Aldar A; Suslov, Evgeniy V; Korchagina, Dina V; Zakharova, Olga D; Zakharenko, Alexandra L; Patel, Jinal; Ayine-Tora, Daniel; Reynisson, Johannes; Leung, Ka Ho Ivanhoe; Volcho, Konstantin P; Salakhutdinov, Nariman F; Lavrik, Olga I

dc.contributor.author	Chepanova, Arina A	en
dc.contributor.author	Mozhaitsev, Evgenii S	en
dc.contributor.author	Munkuev, Aldar A	en
dc.contributor.author	Suslov, Evgeniy V	en
dc.contributor.author	Korchagina, Dina V	en
dc.contributor.author	Zakharova, Olga D	en
dc.contributor.author	Zakharenko, Alexandra L	en
dc.contributor.author	Patel, Jinal	en
dc.contributor.author	Ayine-Tora, Daniel	en
dc.contributor.author	Reynisson, Johannes	en
dc.contributor.author	Leung, Ka Ho Ivanhoe	en
dc.contributor.author	Volcho, Konstantin P	en
dc.contributor.author	Salakhutdinov, Nariman F	en
dc.contributor.author	Lavrik, Olga I	en
dc.date.accessioned	2019-10-08T21:10:30Z	en
dc.date.issued	2019-07-01	en
dc.identifier.citation	Applied Sciences 9(13):18 pages Article number 2767 01 Jul 2019	en
dc.identifier.uri	http://hdl.handle.net/2292/48525	en
dc.language	English	en
dc.publisher	MDPI	en
dc.relation.ispartofseries	APPLIED SCIENCES-BASEL	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Science & Technology	en
dc.subject	Physical Sciences	en
dc.subject	Technology	en
dc.subject	Chemistry, Multidisciplinary	en
dc.subject	Engineering, Multidisciplinary	en
dc.subject	Materials Science, Multidisciplinary	en
dc.subject	Physics, Applied	en
dc.subject	Chemistry	en
dc.subject	Engineering	en
dc.subject	Materials Science	en
dc.subject	Physics	en
dc.subject	topotecan	en
dc.subject	A-549 lung adenocarcinoma cell line l	en
dc.subject	Topoisomerase 1	en
dc.subject	molecular modelling	en
dc.subject	chemical space	en
dc.subject	synergy	en
dc.subject	thermal shift assay	en
dc.subject	intrinsic tryptophan fluorescence binding assay	en
dc.subject	fluorescence biosensor assay	en
dc.subject	EMPIRICAL SCORING FUNCTIONS	en
dc.subject	TOPOISOMERASE-I INHIBITORS	en
dc.subject	PROTEIN-LIGAND DOCKING	en
dc.subject	BIOLOGICAL EVALUATION	en
dc.subject	TDP1	en
dc.subject	REPAIR	en
dc.subject	CAMPTOTHECIN	en
dc.subject	DERIVATIVES	en
dc.subject	FRAGMENTS	en
dc.subject	MECHANISM	en
dc.title	The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges	en
dc.type	Journal Article	en
dc.identifier.doi	10.3390/app9132767	en
pubs.issue	13	en
pubs.volume	9	en
dc.rights.holder	Copyright: The authors	en
pubs.author-url	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000477031900186&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.subtype	Article	en
pubs.subtype	Journal	en
pubs.elements-id	778616	en
pubs.org-id	Academic Services	en
pubs.org-id	Examinations	en
pubs.org-id	Libraries & Learning Services	en
pubs.org-id	Libraries & Learning Services	en
pubs.org-id	Research and Collections	en
pubs.org-id	Research and Collections	en
pubs.org-id	Collection Development and Access	en
pubs.org-id	Collection Development and Access	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
dc.identifier.eissn	2076-3417	en
pubs.number	ARTN 2767	en