The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review.

ResearchSpace Repository

Show simple item record Cormack, Barbara en Harding, Jane en Miller, Steven P en Bloomfield, Francis en 2019-10-21T22:38:00Z en 2019-08-30 en
dc.identifier.citation Nutrients 11(9) 30 Aug 2019 en
dc.identifier.issn 2072-6643 en
dc.identifier.uri en
dc.description.abstract Extremely preterm babies are at increased risk of less than optimal neurodevelopment compared with their term-born counterparts. Optimising nutrition is a promising avenue to mitigate the adverse neurodevelopmental consequences of preterm birth. In this narrative review, we summarize current knowledge on how nutrition, and in particular, protein intake, affects neurodevelopment in extremely preterm babies. Observational studies consistently report that higher intravenous and enteral protein intakes are associated with improved growth and possibly neurodevelopment, but differences in methodologies and combinations of intravenous and enteral nutrition strategies make it difficult to determine the effects of each intervention. Unfortunately, there are few randomized controlled trials of nutrition in this population conducted to determine neurodevelopmental outcomes. Substantial variation in reporting of trials, both of nutritional intakes and of outcomes, limits conclusions from meta-analyses. Future studies to determine the effects of nutritional intakes in extremely preterm babies need to be adequately powered to assess neurodevelopmental outcomes separately in boys and girls, and designed to address the many potential confounders which may have clouded research findings to date. The development of minimal reporting sets and core outcome sets for nutrition research will aid future meta-analyses. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Nutrients en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Brain en
dc.subject Humans en
dc.subject Enteral Nutrition en
dc.subject Child Development en
dc.subject Developmental Disabilities en
dc.subject Infant, Newborn en
dc.subject Female en
dc.subject Male en
dc.subject Infant, Extremely Premature en
dc.title The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review. en
dc.type Journal Article en
dc.identifier.doi 10.3390/nu11092029 en
pubs.issue 9 en
pubs.volume 11 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype review-article en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 780957 en Liggins Institute en LiFePATH en
dc.identifier.eissn 2072-6643 en
pubs.record-created-at-source-date 2019-09-05 en
pubs.dimensions-id 31480225 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record Except where otherwise noted, this item's license is described as


Search ResearchSpace

Advanced Search