Early morphologic changes in trapeziometacarpal joint bones with osteoarthritis

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dc.contributor.author Schneider, Marco en
dc.contributor.author Zhang, Ju en
dc.contributor.author Walker, Cameron en
dc.contributor.author Crisco, J en
dc.contributor.author Weiss, A en
dc.contributor.author Ladd, A en
dc.contributor.author Nielsen, Poul en
dc.contributor.author Besier, Thor en
dc.date.accessioned 2019-10-29T01:00:46Z en
dc.date.issued 2018-10 en
dc.identifier.issn 1522-9653 en
dc.identifier.uri http://hdl.handle.net/2292/48685 en
dc.description.abstract Objective: Characterising the morphological differences between healthy and early osteoarthritic (EOA) trapeziometacarpal (TMC) joints is important for understanding osteoarthritis onset, and early detection is important for treatment and disease management. This study has two aims: first, to characterise morphological differences between healthy and EOA TMC bones. The second aim was to determine the efficacy of using a statistical shape model (SSM) to detect early signs of osteoarthritis (OA). Methods: CT image data of TMC bones from 22 asymptomatic volunteers and 47 patients with EOA were obtained from an ongoing study and used to generate a SSM. A linear discriminant analysis (LDA) classifier was trained on the principal component (PC) weights to characterise features of each group. Multivariable statistical analysis was performed on the PC to investigate morphologic differences. Leave-one-out classification was performed to evaluate the classifiers performance. Results: We found that TMC bones of EOA subjects exhibited a lower aspect ratio (P = 0.042) compared with healthy subjects. The LDA classifier predicted that protrusions (up to 1.5 mm) at the volar beak of the first metacarpal were characteristic of EOA subjects. This was accompanied with widening of the articular surface, deepening of the articular surface, and protruding bone growths along the concave margin. These characteristics resulted in a leave-one-out classification accuracy of 73.9% (95% CI [61.9%, 83.8%]), sensitivity of 89.4%, specificity of 40.9%, and precision of 75.9%. Conclusion: Our findings indicate that morphological degeneration is well underway in the EOA TMC joint, and shows promise for a clinical tool that can detect these features automatically. en
dc.publisher Elsevier en
dc.relation.ispartofseries Osteoarthritis and Cartilage en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Early morphologic changes in trapeziometacarpal joint bones with osteoarthritis en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.joca.2018.06.008 en
pubs.issue 10 en
pubs.begin-page 1338 en
pubs.volume 26 en
dc.rights.holder Copyright: The author en
pubs.end-page 1344 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 780759 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2019-09-12 en
pubs.online-publication-date 2018-07-04 en
pubs.dimensions-id 29981379 en


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