Development of an in vivo magnetic resonance imaging and computer modelling platform to investigate the physiological optics of the crystalline lens.

Show simple item record Pan, Xingzheng en Lie, Alyssa en White, Thomas W en Donaldson, Paul en Vaghefi Rezaei, Seyed en 2019-10-29T01:44:57Z en 2019-09 en
dc.identifier.issn 2156-7085 en
dc.identifier.uri en
dc.description.abstract We have developed and validated in vivo magnetic resonance imaging (MRI) protocols to extract parameters (T2 and geometry) of the human lens that, combined with biometric measures of the eye and optical modelling, enable us to investigate the relative contributions made by the gradient of refractive index (GRIN) and the shape of the lens to the refractive properties of each subject tested. Seven young and healthy participants (mean age: 25.6 ± 3.6 years) underwent an ophthalmic examination, and two sessions of MRI scans using a 3 T clinical magnet. Our MRI protocols for studying lens physiological optics and geometrical measurements were repeatable and reliable, using both 1D (95% confidence interval (CI) for mean differences for exponents = [-2.1, 2.6]) and 2D analysis (anterior T2 CI for differences [-6.4, 8.1] ms; posterior T2 CI for differences [-6.4, 8.3] ms). The lens thickness measured from MRI showed good correlation with that measured with clinical 'gold standard' LenStar (mean differences = [-0.18, 0.2] mm). The predicted refractive errors from ZEMAX had reasonable agreements with participants' clinic records (mean differences = [-1.7, 1.2] D). Quantitative measurements of lens geometry and GRIN with our MRI technique showed high inter-day repeatability. Our clinical MRI technique also provides reliable measures of lens geometry that are comparable to optical biometry. Finally, our ZEMAX optical models produced accurate refractive error and lens power estimations. en
dc.format.medium Electronic-eCollection en
dc.language eng en
dc.relation.ispartofseries Biomedical optics express en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Development of an in vivo magnetic resonance imaging and computer modelling platform to investigate the physiological optics of the crystalline lens. en
dc.type Journal Article en
dc.identifier.doi 10.1364/BOE.10.004462 en
pubs.issue 9 en
pubs.begin-page 4462 en
pubs.volume 10 en
dc.rights.holder Copyright: The author en
pubs.end-page 4478 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 781872 en Bioengineering Institute en ABI Associates en Medical and Health Sciences en Medical Sciences en Physiology Division en Optometry and Vision Science en
dc.identifier.eissn 2156-7085 en
pubs.record-created-at-source-date 2019-10-01 en
pubs.dimensions-id 31565502 en

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