Classification of diffuse light emission profiles for distinguishing skin layer penetration of a needle-free jet injection

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dc.contributor.author Brennan, KA en
dc.contributor.author Ruddy, Bryan en
dc.contributor.author Nielsen, Poul en
dc.contributor.author Taberner, Andrew en
dc.date.accessioned 2019-10-29T01:46:20Z en
dc.date.available 2019-08-20 en
dc.date.issued 2019-10-01 en
dc.identifier.issn 2156-7085 en
dc.identifier.uri http://hdl.handle.net/2292/48708 en
dc.description.abstract In this work, a system is developed for tracking the skin layer to which a needle-free jet injection of fluid has penetrated by incorporating a laser beam into the jet, and measuring the diffuse light emitted from skin tissue. Monitoring the injection in this way offers the ability to improve the reliability of drug delivery with this transdermal delivery method. A laser beam, axially aligned with a jet of fluid, created a distribution of diffuse light around the injection site that varied as the injection progressed. High-speed videography was used to capture the diffuse light emission from laser-coupled jet injections into samples of porcine skin, fat, and muscle. The injection produced a distribution of diffuse light around the injection site that varied as the injection descended. A classifier, trained to distinguish whether the light source was located in the fat or muscle from surface intensity profile measurements, correctly identified the injected layer in 97.2% of the cases when cross-examined against estimates using the light distribution emitted from the side of the sample. en
dc.publisher Optical Society of America en
dc.relation.ispartofseries Biomedical Optics Express en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Classification of diffuse light emission profiles for distinguishing skin layer penetration of a needle-free jet injection en
dc.type Journal Article en
dc.identifier.doi 10.1364/BOE.10.005081 en
pubs.issue 10 en
pubs.begin-page 5081 en
pubs.volume 10 en
dc.rights.holder Copyright: The author en
pubs.end-page 5092 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 780974 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2019-09-19 en
pubs.online-publication-date 2019-09-13 en
pubs.dimensions-id 31646031 en


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