dc.contributor.author |
Diprose, William |
en |
dc.contributor.author |
Wang, Michael |
en |
dc.contributor.author |
McFetridge, Andrew |
en |
dc.contributor.author |
Sutcliffe, James |
en |
dc.contributor.author |
Barber, Peter |
en |
dc.date.accessioned |
2019-10-29T02:27:08Z |
en |
dc.date.issued |
2020-01 |
en |
dc.identifier.issn |
1759-8478 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/48723 |
en |
dc.description.abstract |
BACKGROUND:In ischemic stroke, increased glycated hemoglobin (HbA1c) and glucose levels are associated with worse outcome following thrombolysis, and possibly, endovascular thrombectomy. OBJECTIVE:To evaluate the association between admission HbA1c and glucose levels and outcome following endovascular thrombectomy. METHODS:Consecutive patients treated with endovascular thrombectomy with admission HbA1c and glucose levels were included. The primary outcome was functional independence, defined as a modified Rankin Scale score of 0-2 at 3 months. Secondary outcomes included successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b-3), early neurological improvement (reduction in National Institutes of Health Stroke Scale (NIHSS) score ≥8 points, or NIHSS score of 0-1 at 24 hours), symptomatic intracerebral hemorrhage (sICH), and mortality at 3 months. RESULTS:223 patients (136 (61%) men; mean±SD age 64.5±14.6) were included. The median (IQR) HbA1c and glucose were 39 (36-45) mmol/mol and 6.9 (5.8-8.4) mmol/L, respectively. Multiple logistic regression analysis demonstrated that increasing HbA1c levels (per 10 mmol/mol) were associated with reduced functional independence (OR=0.76; 95% CI 0.60-0.96; p=0.02), increased sICH (OR=1.33; 95% CI 1.03 to 1.71; p=0.03), and increased mortality (OR=1.26; 95% CI 1.01 to 1.57; p=0.04). There were no significant associations between glucose levels and outcome measures (all p>0.05). CONCLUSIONS:HbA1c levels are an independent predictor of worse outcome following endovascular thrombectomy. The addition of HbA1c to decision-support tools for endovascular thrombectomy should be evaluated in future studies. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of neurointerventional surgery |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Brain Ischemia |
en |
dc.subject |
Treatment Outcome |
en |
dc.subject |
Thrombectomy |
en |
dc.subject |
Registries |
en |
dc.subject |
Retrospective Studies |
en |
dc.subject |
Prospective Studies |
en |
dc.subject |
Aged |
en |
dc.subject |
Aged, 80 and over |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Stroke |
en |
dc.subject |
Endovascular Procedures |
en |
dc.subject |
Biomarkers |
en |
dc.subject |
Glycated Hemoglobin A |
en |
dc.subject |
Outcome Assessment, Health Care |
en |
dc.title |
Glycated hemoglobin (HbA1c) and outcome following endovascular thrombectomy for ischemic stroke. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1136/neurintsurg-2019-015023 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
30 |
en |
pubs.volume |
12 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
32 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
774437 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Ophthalmology Department |
en |
pubs.org-id |
Surgery Department |
en |
dc.identifier.eissn |
1759-8486 |
en |
pubs.record-created-at-source-date |
2019-06-01 |
en |
pubs.dimensions-id |
31147437 |
en |