The Māori and Pacific specific CREBRF variant and adult height.

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dc.contributor.author Metcalfe, Louise K en
dc.contributor.author Krishnan, Mohanraj en
dc.contributor.author Turner, Nigel en
dc.contributor.author Yaghootkar, Hanieh en
dc.contributor.author Merry, Troy en
dc.contributor.author Dewes, Ofanaite en
dc.contributor.author Hindmarsh, Jennie Harré en
dc.contributor.author de Zoysa, Janak en
dc.contributor.author Dalbeth, Nicola en
dc.contributor.author Stamp, Lisa K en
dc.contributor.author Merriman, Tony R en
dc.contributor.author Smith, Greg en
dc.contributor.author Shepherd, Peter en
dc.contributor.author Murphy, Rinki en
dc.date.accessioned 2019-10-29T02:38:49Z en
dc.date.issued 2019-09-22 en
dc.identifier.issn 0307-0565 en
dc.identifier.uri http://hdl.handle.net/2292/48729 en
dc.description.abstract BACKGROUND:The CREBRF missense variant (p.Arg457Gln) is paradoxically associated with lower risk of type 2 diabetes, yet higher body mass index (BMI). Here we sought to determine whether this CREBRF variant might be associated with adult height. METHODS:Linear regression was used to analyse the association of the CREBRF minor (A) allele with height in 2286 Māori and Pacific adults living in Aotearoa/New Zealand. A potential type 2 diabetes index event was corrected to account for a bias that may be the cause of paradoxical association between the CREBRF diabetes-protective allele and higher BMI and height. RESULTS:The CREBRF protective allele was associated with increased adult height (ß = 1.25 cm, P = 3.9 × 10-6), with the effect being more pronounced in males. The lower odds of diabetes remained similar when analyses were adjusted for height (OR = 0.67-0.65). We found no evidence of a diabetes index event bias to explain the paradoxical effect of CREBRF with either BMI or height and diabetes. The orthologous CREBRF p.Arg457Gln variant was created in knock-in mice to independently assess the effect of the variant, and length was found to be greater in male mice at 8 weeks of age. CONCLUSION:These data taken together indicate that CREBRF p.Arg457Gln is associated with taller stature in Māori and Pacific adults. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries International journal of obesity (2005) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title The Māori and Pacific specific CREBRF variant and adult height. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41366-019-0437-6 en
dc.rights.holder Copyright: The author en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 783354 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Molecular Medicine en
pubs.org-id Nutrition en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1476-5497 en
pubs.record-created-at-source-date 2019-09-24 en
pubs.dimensions-id 31543511 en


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