Contribution of ERMES subunits to mature peroxisome abundance

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dc.contributor.author Esposito, M en
dc.contributor.author Denmat, SH-L en
dc.contributor.author Delahodde, A en
dc.date.accessioned 2019-11-04T02:40:42Z en
dc.date.issued 2019-03-25 en
dc.identifier.citation PLoS ONE 14(3):19 pages Article number e0214287 25 Mar 2019 en
dc.identifier.issn 1932-6203 en
dc.identifier.uri http://hdl.handle.net/2292/48812 en
dc.description.abstract Eukaryotic organelles share different components and establish physical contacts to communicate throughout the cell. One of the best-recognized examples of such interplay is the metabolic cooperation and crosstalk between mitochondria and peroxisomes, both organelles being functionally and physically connected and linked to the endoplasmic reticulum (ER). In Saccharomyces cerevisiae, mitochondria are linked to the ER by the ERMES complex that facilitates inter-organelle calcium and phospholipid exchanges. Recently, peroxisome-mitochondria contact sites (PerMit) have been reported and among Permit tethers, one component of the ERMES complex (Mdm34) was shown to interact with the peroxin Pex11, suggesting that the ERMES complex or part of it may be involved in two membrane contact sites (ER-mitochondria and peroxisome- mitochondria). This opens the possibility of exchanges between these three membrane compartments. Here, we investigated in details the role of each ERMES subunit on peroxisome abundance. First, we confirmed previous studies from other groups showing that absence of Mdm10 or Mdm12 leads to an increased number of mature peroxisomes. Secondly, we showed that this is not simply due to respiratory function defect, mitochondrial DNA (mtDNA) loss or mitochondrial network alteration. Finally, we present evidence that the contribution of ERMES subunits Mdm10 and Mdm12 to peroxisome number involves two different mechanisms. en
dc.publisher Public Library of Science (PLoS) en
dc.relation.ispartofseries PLoS ONE en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.title Contribution of ERMES subunits to mature peroxisome abundance en
dc.type Journal Article en
dc.identifier.doi 10.1371/journal.pone.0214287 en
pubs.issue 3 en
pubs.volume 14 en
dc.rights.holder Copyright: The authors en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 777440 en
pubs.number e0214287 en
pubs.record-created-at-source-date 2019-07-31 en


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