dc.contributor.author |
Lock, Alistair |
en |
dc.contributor.author |
Cornish, Jillian |
en |
dc.contributor.author |
Musson, David |
en |
dc.date.accessioned |
2019-11-22T01:09:16Z |
en |
dc.date.issued |
2019-07-12 |
en |
dc.identifier.citation |
Journal of Functional Biomaterials 10(3):15 pages Article number 31 01 Sep 2019 |
en |
dc.identifier.issn |
2079-4983 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49047 |
en |
dc.description.abstract |
Grafts are required to restore tissue integrity and function. However, current gold standard autografting techniques yield limited harvest, with high rates of complication. In the search for viable substitutes, the number of biomaterials being developed and studied has increased rapidly. To date, low clinical uptake has accompanied inherently high failure rates, with immune rejection a specific and common end result. The objective of this review article was to evaluate published immune assays evaluating biomaterials, and to stress the value that incorporating immune assessment into evaluations carries. Immunogenicity assays have had three areas of focus: cell viability, maturation and activation, with the latter being the focus in the majority of the literature due to its relevance to functional outcomes. With recent studies suggesting poor correlation between current in vitro and in vivo testing of biomaterials, in vitro immune response assays may be more relevant and enhance ability in predicting acceptance prior to in vivo application. Uptake of in vitro immune response assessment will allow for substantial reductions in experimental time and resources, including unnecessary and unethical animal use, with a simultaneous decrease in inappropriate biomaterials reaching clinic. This improvement in bench to bedside safety is paramount to reduce patient harm. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of functional biomaterials |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.title |
The Role of In Vitro Immune Response Assessment for Biomaterials. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3390/jfb10030031 |
en |
pubs.issue |
3 |
en |
pubs.volume |
10 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
784270 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
2079-4983 |
en |
pubs.record-created-at-source-date |
2019-07-25 |
en |
pubs.dimensions-id |
31336893 |
en |