Closing the loop: Validation of implantable cardiac devices with computational heart models

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dc.contributor.author Ai, Weiwei en
dc.contributor.author Patel, Nitish en
dc.contributor.author Roop, Parthasarathi en
dc.contributor.author Malik, Avinash en
dc.contributor.author Trew, Mark en
dc.date.accessioned 2019-11-24T21:38:27Z en
dc.date.issued 2019 en
dc.identifier.citation IEEE Journal of Biomedical and Health Informatics 10 pages 2019 en
dc.identifier.issn 2168-2194 en
dc.identifier.uri http://hdl.handle.net/2292/49076 en
dc.description.abstract Objective: Cardiovascular Implantable Electronic Devices (CIEDs) are used extensively for treating life-threatening conditions such as bradycardia, atrioventricular block and heart failure. The complicated heterogeneous physical dynamics of patients provide distinct challenges to device development and validation. We address this problem by proposing a device testing framework within the in-silico closed-loop context of patient physiology. Methods: We develop an automated framework to validate CIEDs in closed-loop with a high-level physiologically based computational heart model. The framework includes test generation, execution and evaluation, which automatically guides an integrated stochastic optimization algorithm for exploration of physiological conditions. Conclusion: The results show that using a closed loop device-heart model framework can achieve high system test coverage, while the heart model provides clinically relevant responses. The simulated findings of pacemaker mediated tachycardia risk evaluation agree well with the clinical observations. Furthermore, we illustrate how device programming parameter selection affects the treatment efficacy for specific physiological conditions. Significance: This work demonstrates that incorporating model based closed-loop testing of CIEDs into their design provides important indications of safety and efficacy under constrained physiological conditions. en
dc.publisher Institute of Electrical and Electronics Engineers en
dc.relation.ispartofseries IEEE Journal of Biomedical and Health Informatics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://www.ieee.org/publications/rights/author-posting-policy.html en
dc.title Closing the loop: Validation of implantable cardiac devices with computational heart models en
dc.type Journal Article en
dc.identifier.doi 10.1109/JBHI.2019.2947007 en
dc.rights.holder Copyright: IEEE en
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/31613786 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 784145 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Department of Electrical, Computer and Software Engineering en
dc.identifier.eissn 2168-2208 en
pubs.record-created-at-source-date 2019-10-16 en
pubs.online-publication-date 2019-10-11 en
pubs.dimensions-id 31613786 en


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