dc.contributor.author |
Bolland, Mark |
en |
dc.contributor.author |
Horne, Anne |
en |
dc.contributor.author |
Briggs, Simon E |
en |
dc.contributor.author |
Thomas, Mark |
en |
dc.contributor.author |
Reid, Ian |
en |
dc.contributor.author |
Gamble, Gregory |
en |
dc.contributor.author |
Grey, Andrew |
en |
dc.date.accessioned |
2019-11-25T01:00:35Z |
en |
dc.date.issued |
2019-10 |
en |
dc.identifier.citation |
Calcified tissue international 105(4):423-429 Oct 2019 |
en |
dc.identifier.issn |
0171-967X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49133 |
en |
dc.description.abstract |
INTRODUCTION:Most prospective studies of bone mineral density (BMD) in HIV-infected cohorts taking antiretroviral therapy (ART) have been of short duration, typically < 3 years. Such studies have reported short-term stable or increasing BMD. We assessed whether this BMD stability persists for > 10 years in middle-aged and older men established on ART. METHODS:A 12-year, prospective, longitudinal study in 44 HIV-infected men treated with ART who had measurements of BMD at the lumbar spine, proximal femur and total body at baseline, 2, 6 and 12 years. RESULTS:At baseline, the mean age of participants was 49 years, the mean duration of HIV infection was 8 years, and the mean duration of ART was 50 months. After 12 years, BMD increased by 6.9% (95% CI 3.4 to 10.3) at the lumbar spine, and remained stable (range of BMD change: - 0.6% to 0.0%) at the total hip, femoral neck and total body. Only two individuals had a decrease of > 10% in BMD at any site during follow-up and both decreases in BMD were explained by co-morbid illnesses. CONCLUSIONS:BMD remained stable over 12 years in middle-aged and older HIV-infected men treated with ART. Monitoring BMD in men established on ART who do not have risk factors for BMD loss is not necessary. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Calcified tissue international |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Long-Term Stable Bone Mineral Density in HIV-Infected Men Without Risk Factors for Osteoporosis Treated with Antiretroviral Therapy. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00223-019-00579-0 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
423 |
en |
pubs.volume |
105 |
en |
dc.rights.holder |
Copyright: Springer Nature 2019 |
en |
pubs.end-page |
429 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
775992 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1432-0827 |
en |
pubs.record-created-at-source-date |
2019-06-29 |
en |
pubs.dimensions-id |
31250043 |
en |