Long-Term Stable Bone Mineral Density in HIV-Infected Men Without Risk Factors for Osteoporosis Treated with Antiretroviral Therapy.

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dc.contributor.author Bolland, Mark en
dc.contributor.author Horne, Anne en
dc.contributor.author Briggs, Simon E en
dc.contributor.author Thomas, Mark en
dc.contributor.author Reid, Ian en
dc.contributor.author Gamble, Gregory en
dc.contributor.author Grey, Andrew en
dc.date.accessioned 2019-11-25T01:00:35Z en
dc.date.issued 2019-10 en
dc.identifier.citation Calcified tissue international 105(4):423-429 Oct 2019 en
dc.identifier.issn 0171-967X en
dc.identifier.uri http://hdl.handle.net/2292/49133 en
dc.description.abstract INTRODUCTION:Most prospective studies of bone mineral density (BMD) in HIV-infected cohorts taking antiretroviral therapy (ART) have been of short duration, typically < 3 years. Such studies have reported short-term stable or increasing BMD. We assessed whether this BMD stability persists for > 10 years in middle-aged and older men established on ART. METHODS:A 12-year, prospective, longitudinal study in 44 HIV-infected men treated with ART who had measurements of BMD at the lumbar spine, proximal femur and total body at baseline, 2, 6 and 12 years. RESULTS:At baseline, the mean age of participants was 49 years, the mean duration of HIV infection was 8 years, and the mean duration of ART was 50 months. After 12 years, BMD increased by 6.9% (95% CI 3.4 to 10.3) at the lumbar spine, and remained stable (range of BMD change: - 0.6% to 0.0%) at the total hip, femoral neck and total body. Only two individuals had a decrease of > 10% in BMD at any site during follow-up and both decreases in BMD were explained by co-morbid illnesses. CONCLUSIONS:BMD remained stable over 12 years in middle-aged and older HIV-infected men treated with ART. Monitoring BMD in men established on ART who do not have risk factors for BMD loss is not necessary. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Calcified tissue international en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Long-Term Stable Bone Mineral Density in HIV-Infected Men Without Risk Factors for Osteoporosis Treated with Antiretroviral Therapy. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s00223-019-00579-0 en
pubs.issue 4 en
pubs.begin-page 423 en
pubs.volume 105 en
dc.rights.holder Copyright: Springer Nature 2019 en
pubs.end-page 429 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 775992 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Molecular Medicine en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1432-0827 en
pubs.record-created-at-source-date 2019-06-29 en
pubs.dimensions-id 31250043 en

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