A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery.

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dc.contributor.author Long, Jingjunjiao en
dc.contributor.author Etxeberria, Alaitz Etxabide en
dc.contributor.author Nand, Ashveen V en
dc.contributor.author Bunt, Craig R en
dc.contributor.author Ray, Sudip en
dc.contributor.author Seyfoddin, Ali en
dc.date.accessioned 2019-11-25T21:47:37Z en
dc.date.issued 2019-11 en
dc.identifier.issn 0928-4931 en
dc.identifier.uri http://hdl.handle.net/2292/49206 en
dc.description.abstract A chitosan-pectin (CS-PEC) biopolymeric hydrogel wound dressing was investigated for lidocaine delivery. Here we demonstrate for the first time the feasibility of three-dimensional (3D) printed CS-PEC hydrogel incorporating the local anaesthetic drug lidocaine hydrochloride (LDC) as a potential wound dressing candidate. The hydrogels were prepared by physical crosslinking of CS and PEC polysaccharides. The scaffolds were printed using an extrusion-based 3D printer using a mechanical positive displacement dispensing system followed by lyophilisation. The 3D printed hydrogels showed good printability, dimensional integrity and self-adhesion to skin. The high swelling ratio and water absorption of 3D printed hydrogels indicated suitability for absorbing exudates and maintaining a moist wound healing environment. Fourier transform infrared (FTIR) spectroscopy results indicated that the CS-PEC hydrogel was formed by hydrogen bonds. Incorporation of LDC in the hydrogel did not interfere with its functional stability. In vitro drug release studies of LDC over 6 h fitted the Korsmeyer-Peppas model. This work demonstrates the possibility of a 3D printed hydrogel as a suitable candidate for wound dressings. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Materials science & engineering. C, Materials for biological applications en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Water en
dc.subject Lidocaine en
dc.subject Chitosan en
dc.subject Pectins en
dc.subject Hydrogels en
dc.subject Drug Delivery Systems en
dc.subject Calorimetry, Differential Scanning en
dc.subject Spectroscopy, Fourier Transform Infrared en
dc.subject Feasibility Studies en
dc.subject Bandages en
dc.subject Kinetics en
dc.subject Adhesiveness en
dc.subject Tissue Scaffolds en
dc.subject Drug Liberation en
dc.subject Printing, Three-Dimensional en
dc.title A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.msec.2019.109873 en
pubs.begin-page 109873 en
pubs.volume 104 en
dc.rights.holder Copyright: The author en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 775871 en
dc.identifier.eissn 1873-0191 en
pubs.record-created-at-source-date 2019-09-11 en
pubs.dimensions-id 31500054 en

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