dc.contributor.author |
Bhusal, Ram Prasad |
en |
dc.contributor.author |
Jiao, Wanting |
en |
dc.contributor.author |
Kwai, Brooke |
en |
dc.contributor.author |
Reynisson, Johannes |
en |
dc.contributor.author |
Collins, Annabelle J |
en |
dc.contributor.author |
Sperry, Jonathan |
en |
dc.contributor.author |
Bashiri, Ghader |
en |
dc.contributor.author |
Leung, Ka Ho Ivanhoe |
en |
dc.date.accessioned |
2019-11-26T02:31:28Z |
en |
dc.date.issued |
2019-10-11 |
en |
dc.identifier.citation |
Nature communications 10(1):4639 11 Oct 2019 |
en |
dc.identifier.issn |
2041-1723 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49221 |
en |
dc.description.abstract |
Isocitrate lyase is important for lipid utilisation by Mycobacterium tuberculosis but its ICL2 isoform is poorly understood. Here we report that binding of the lipid metabolites acetyl-CoA or propionyl-CoA to ICL2 induces a striking structural rearrangement, substantially increasing isocitrate lyase and methylisocitrate lyase activities. Thus, ICL2 plays a pivotal role regulating carbon flux between the tricarboxylic acid (TCA) cycle, glyoxylate shunt and methylcitrate cycle at high lipid concentrations, a mechanism essential for bacterial growth and virulence. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Nature communications |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.title |
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/s41467-019-12614-7 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
4639 |
en |
pubs.volume |
10 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
784192 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
2041-1723 |
en |
pubs.record-created-at-source-date |
2019-10-13 |
en |
pubs.dimensions-id |
31604954 |
en |