The role of ghrelin and leptin in intra-pancreatic fat deposition

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dc.contributor.advisor Petrov, M en Nguyen, Nhu en 2019-12-05T19:53:32Z en 2019 en
dc.identifier.uri en
dc.description Full Text is available to authenticated members of The University of Auckland only. en
dc.description.abstract Obesity, as identified by body mass index (BMI), is a global epidemic. There has been emerging evidence on abdominal obesity playing a role in metabolic disease, which in turn increases the risk of developing many non-communicable diseases (most significantly diabetes mellitus type-2). Recently, ectopic fat accumulations within parenchymatous organs such as the liver and the pancreas have been gaining a lot of research attention. While there has been an extensive investigation on fatty liver as a predisposition to many chronic illnesses, having a fatty pancreas only recently gained more research attention. Leptin and ghrelin, two key players in appetite regulation, have been found to play a role on body fat accumulation. This thesis aims to investigate the association of these two hormones on intra-pancreatic fat in the context of acute pancreatitis. A total of 94 AP patients were recruited, and linear regression analyses were completed across several models that were unadjusted and adjusted for patient- and pancreatitis-related factors during both fasting states and postprandially. The results of this thesis demonstrated that leptin and leptin/ghrelin ratio were significantly associated with intra-pancreatic fat accumulation across all adjusted models during fasting states. Leptin was found to be positively correlated with intra-pancreatic fat deposition postprandially with an adjusted model for age and sex. There was no association found between ghrelin and intra-pancreatic fat accumulation during both fasting and postprandial states. This thesis provides insights into the role of leptin and ghrelin in intra-pancreatic fat accumulation, thus pancreatitis pathophysiology. Additionally, it provides the first investigation of ghrelin and leptin/ghrelin ratio in the context of acute pancreatitis using Magnetic Resonance Imaging-derived quantification of intrapancreatic fat. This thesis builds upon current understanding of AP as a disease and paves the way for future studies of leptin and ghrelin within and beyond the field of pancreatology. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA99265206714102091 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Full Text is available to authenticated members of The University of Auckland only. en
dc.rights.uri en
dc.rights.uri en
dc.title The role of ghrelin and leptin in intra-pancreatic fat deposition en
dc.type Thesis en Nutrition and Dietetics en The University of Auckland en Masters en
dc.rights.holder Copyright: The author en
pubs.elements-id 788695 en
pubs.record-created-at-source-date 2019-12-06 en

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