Mitochondria-targeted antioxidants and skeletal muscle function

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Show simple item record Broome, SC en Woodhead, JST en Merry, Troy en 2020-01-09T00:27:29Z en 2018-08-08 en
dc.identifier.citation Antioxidants 7(8):12 pages Article number 107 Aug 2018 en
dc.identifier.uri en
dc.description.abstract One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targeting antioxidants to the mitochondria in an effort to prevent or treat muscle dysfunction and damage associated with disease and injury. Paradoxically, however, ROS also act as important signalling molecules in controlling cellular homeostasis, and therefore caution must be taken when supplementing with antioxidants. It is possible that mitochondria-targeted antioxidants may limit oxidative stress without suppressing ROS from non-mitochondrial sources that might be important for cell signalling. Therefore, in this review, we summarise literature relating to the effect of mitochondria-targeted antioxidants on skeletal muscle function. Overall, mitochondria-targeted antioxidants appear to exert beneficial effects on mitochondrial capacity and function, insulin sensitivity and age-related declines in muscle function. However, it seems that this is dependent on the type of mitochondrial-trageted antioxidant employed, and its specific mechanism of action, rather than simply targeting to the mitochondria. en
dc.description.uri en
dc.publisher MDPI AG en
dc.relation.ispartofseries Antioxidants en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.title Mitochondria-targeted antioxidants and skeletal muscle function en
dc.type Journal Article en
dc.identifier.doi 10.3390/antiox7080107 en
pubs.issue 8 en
pubs.volume 7 en
dc.rights.holder Copyright: The authors en en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 788019 en Medical and Health Sciences en Medical Sciences en Nutrition en
dc.identifier.eissn 2076-3921 en
pubs.number 107 en
pubs.record-created-at-source-date 2019-11-28 en 2018-08-08 en

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