The slow force response to stretch: Controversy and contradictions.

Show simple item record Dowrick, Jarrah en Tran, Kenneth en Loiselle, Denis en Nielsen, Poul en Taberner, Andrew en Han, June en Ward, Marie-Louise en 2020-01-10T01:13:07Z en 2019-05 en
dc.identifier.citation Acta physiologica (Oxford, England) 226(1):e13250 May 2019 en
dc.identifier.issn 1748-1708 en
dc.identifier.uri en
dc.description.abstract When exposed to an abrupt stretch, cardiac muscle exhibits biphasic active force enhancement. The initial, instantaneous, force enhancement is well explained by the Frank-Starling mechanism. However, the cellular mechanisms associated with the second, slower phase remain contentious. This review explores hypotheses regarding this "slow force response" with the intention of clarifying some apparent contradictions in the literature. The review is partitioned into three sections. The first section considers pathways that modify the intracellular calcium handling to address the role of the sarcoplasmic reticulum in the mechanism underlying the slow force response. The second section focuses on extracellular calcium fluxes and explores the identity and contribution of the stretch-activated, non-specific, cation channels as well as signalling cascades associated with G-protein coupled receptors. The final section introduces promising candidates for the mechanosensor(s) responsible for detecting the stretch perturbation. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Acta physiologica (Oxford, England) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Myocardium en
dc.subject Animals en
dc.subject Myocardial Contraction en
dc.subject Stress, Mechanical en
dc.title The slow force response to stretch: Controversy and contradictions. en
dc.type Journal Article en
dc.identifier.doi 10.1111/apha.13250 en
pubs.issue 1 en
pubs.begin-page e13250 en
pubs.volume 226 en
dc.rights.holder Copyright: 2019 Scandinavian Physiological Society. en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 761039 en Bioengineering Institute en ABI Associates en Engineering en Engineering Science en Medical and Health Sciences en Medical Sciences en Physiology Division en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1748-1716 en
pubs.record-created-at-source-date 2019-01-08 en
pubs.dimensions-id 30614655 en

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