dc.contributor.author |
Dowrick, Jarrah |
en |
dc.contributor.author |
Tran, Kenneth |
en |
dc.contributor.author |
Loiselle, Denis |
en |
dc.contributor.author |
Nielsen, Poul |
en |
dc.contributor.author |
Taberner, Andrew |
en |
dc.contributor.author |
Han, June |
en |
dc.contributor.author |
Ward, Marie-Louise |
en |
dc.date.accessioned |
2020-01-10T01:13:07Z |
en |
dc.date.issued |
2019-05 |
en |
dc.identifier.citation |
Acta physiologica (Oxford, England) 226(1):e13250 May 2019 |
en |
dc.identifier.issn |
1748-1708 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49478 |
en |
dc.description.abstract |
When exposed to an abrupt stretch, cardiac muscle exhibits biphasic active force enhancement. The initial, instantaneous, force enhancement is well explained by the Frank-Starling mechanism. However, the cellular mechanisms associated with the second, slower phase remain contentious. This review explores hypotheses regarding this "slow force response" with the intention of clarifying some apparent contradictions in the literature. The review is partitioned into three sections. The first section considers pathways that modify the intracellular calcium handling to address the role of the sarcoplasmic reticulum in the mechanism underlying the slow force response. The second section focuses on extracellular calcium fluxes and explores the identity and contribution of the stretch-activated, non-specific, cation channels as well as signalling cascades associated with G-protein coupled receptors. The final section introduces promising candidates for the mechanosensor(s) responsible for detecting the stretch perturbation. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Acta physiologica (Oxford, England) |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html |
en |
dc.subject |
Myocardium |
en |
dc.subject |
Animals |
en |
dc.subject |
Myocardial Contraction |
en |
dc.subject |
Stress, Mechanical |
en |
dc.title |
The slow force response to stretch: Controversy and contradictions. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/apha.13250 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
e13250 |
en |
pubs.volume |
226 |
en |
dc.rights.holder |
Copyright: 2019 Scandinavian Physiological Society. |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
761039 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1748-1716 |
en |
pubs.record-created-at-source-date |
2019-01-08 |
en |
pubs.dimensions-id |
30614655 |
en |