A Core Outcome Set for the prevention and treatment of fetal GROwth restriction: deVeloping Endpoints: the COSGROVE study.

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dc.contributor.author Healy, Patricia en
dc.contributor.author Gordijn, Sanne J en
dc.contributor.author Ganzevoort, Wessel en
dc.contributor.author Beune, Irene M en
dc.contributor.author Baschat, Ahmet en
dc.contributor.author Khalil, Asma en
dc.contributor.author Kenny, Louise en
dc.contributor.author Bloomfield, Francis en
dc.contributor.author Daly, Mandy en
dc.contributor.author Kirkham, Jamie en
dc.contributor.author Devane, Declan en
dc.contributor.author Papageorghiou, Aris T en
dc.date.accessioned 2020-01-10T01:13:42Z en
dc.date.issued 2019-10 en
dc.identifier.citation American journal of obstetrics and gynecology 221(4):339.e1-339.e10 Oct 2019 en
dc.identifier.issn 0002-9378 en
dc.identifier.uri http://hdl.handle.net/2292/49479 en
dc.description.abstract BACKGROUND:Fetal growth restriction refers to a fetus that does not reach its genetically predetermined growth potential. It is well-recognized that growth-restricted fetuses are at increased risk of both short- and long-term adverse outcomes. Systematic evaluation of the evidence from clinical trials of fetal growth restriction is often difficult because of variation in the outcomes that are measured and reported. The development of core outcome sets for fetal growth restriction studies would enable future trials to measure similar meaningful outcomes. OBJECTIVE:The purpose of this study was to develop core outcome sets for trials of prevention or treatment of fetal growth restriction. STUDY DESIGN:This was a Delphi consensus study. A comprehensive literature review was conducted to identify outcomes that were reported in studies of prevention or treatment of fetal growth restriction. All outcomes were presented for prioritization to key stakeholders (135 healthcare providers, 68 researchers/academics, and 35 members of the public) in 3 rounds of online Delphi surveys. A priori consensus criteria were used to reach agreement on the final outcomes for inclusion in the core outcome set at a face-to-face meeting with 5 healthcare providers, 5 researchers/academics, and 6 maternity service users. RESULTS:In total, 22 outcomes were included in the final core outcome set. These outcomes were grouped under 4 domains: maternal (n=4), fetal (n=1), neonatal (n=12), and childhood (n=5). CONCLUSION:The Core Outcome Set for the prevention and treatment of fetal GROwth restriction: deVeloping Endpoints study identified a large number of potentially relevant outcomes and then reached consensus on those factors that, as a minimum, should be measured and reported in all future trials of prevention or treatment of fetal growth restriction. This will enable future trials to measure similar meaningful outcomes and to ensure that findings from different studies can be compared and combined. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries American journal of obstetrics and gynecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Humans en
dc.subject Enterocolitis, Necrotizing en
dc.subject Bronchopulmonary Dysplasia en
dc.subject Hearing Loss en
dc.subject Cerebral Palsy en
dc.subject Hypoxia-Ischemia, Brain en
dc.subject Vision Disorders en
dc.subject Fetal Growth Retardation en
dc.subject Eclampsia en
dc.subject Pre-Eclampsia en
dc.subject Premature Birth en
dc.subject Birth Weight en
dc.subject Respiration, Artificial en
dc.subject Consensus en
dc.subject Gestational Age en
dc.subject Pregnancy en
dc.subject Delphi Technique en
dc.subject Infant, Newborn en
dc.subject Infant, Low Birth Weight en
dc.subject Female en
dc.subject Stillbirth en
dc.subject Maternal Death en
dc.subject Perinatal Death en
dc.subject Cognitive Dysfunction en
dc.subject Outcome Assessment, Health Care en
dc.title A Core Outcome Set for the prevention and treatment of fetal GROwth restriction: deVeloping Endpoints: the COSGROVE study. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ajog.2019.05.039 en
pubs.issue 4 en
pubs.begin-page 339.e1 en
pubs.volume 221 en
dc.rights.holder Copyright: The authors en
pubs.end-page 339.e10 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 780714 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
dc.identifier.eissn 1097-6868 en
pubs.record-created-at-source-date 2019-06-02 en
pubs.dimensions-id 31152710 en

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