Variation in outcome reporting in randomized controlled trials of interventions for prevention and treatment of fetal growth restriction.

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dc.contributor.author Townsend, R en
dc.contributor.author Sileo, F en
dc.contributor.author Stocker, L en
dc.contributor.author Kumbay, H en
dc.contributor.author Healy, P en
dc.contributor.author Gordijn, S en
dc.contributor.author Ganzevoort, W en
dc.contributor.author Beune, I en
dc.contributor.author Baschat, A en
dc.contributor.author Kenny, L en
dc.contributor.author Bloomfield, Francis en
dc.contributor.author Daly, M en
dc.contributor.author Devane, D en
dc.contributor.author Papageorghiou, A en
dc.contributor.author Khalil, A en
dc.date.accessioned 2020-01-10T03:09:59Z en
dc.date.issued 2019-05 en
dc.identifier.issn 0960-7692 en
dc.identifier.uri http://hdl.handle.net/2292/49493 en
dc.description.abstract OBJECTIVE:Although fetal growth restriction (FGR) is well known to be associated with adverse outcomes for the mother and offspring, effective interventions for the management of FGR are yet to be established. Trials reporting interventions for the prevention and treatment of FGR may be limited by heterogeneity in the underlying pathophysiology. The aim of this study was to conduct a systematic review of outcomes reported in randomized controlled trials (RCTs) assessing interventions for the prevention or treatment of FGR, in order to identify and categorize the variation in outcome reporting. METHODS:MEDLINE, EMBASE and The Cochrane Library were searched from inception until August 2018 for RCTs investigating therapies for the prevention and treatment of FGR. Studies were assessed systematically and data on outcomes that were reported in the included studies were extracted and categorized. The methodological quality of the included studies was assessed using the Jadad score. RESULTS:The search identified 2609 citations, of which 153 were selected for full-text review and 72 studies (68 trials) were included in the final analysis. There were 44 trials relating to the prevention of FGR and 24 trials investigating interventions for the treatment of FGR. The mean Jadad score of all studies was 3.07, and only nine of them received a score of 5. We identified 238 outcomes across the included studies. The most commonly reported were birth weight (88.2%), gestational age at birth (72.1%) and small-for-gestational age (67.6%). Few studies reported on any measure of neonatal morbidity (27.9%), while adverse effects of the interventions were reported in only 17.6% of trials. CONCLUSIONS:There is significant variation in outcome reporting across RCTs of therapies for the prevention and treatment of FGR. The clinical applicability of future research would be enhanced by the development of a core outcome set for use in future trials. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Fetal Growth Retardation en
dc.subject Pregnancy en
dc.subject Research Design en
dc.subject Female en
dc.subject Randomized Controlled Trials as Topic en
dc.subject Data Accuracy en
dc.title Variation in outcome reporting in randomized controlled trials of interventions for prevention and treatment of fetal growth restriction. en
dc.type Journal Article en
dc.identifier.doi 10.1002/uog.20189 en
pubs.issue 5 en
pubs.begin-page 598 en
pubs.volume 53 en
dc.rights.holder Copyright: The author en
pubs.end-page 608 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Systematic Review en
pubs.subtype Journal Article en
pubs.elements-id 769288 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
dc.identifier.eissn 1469-0705 en
pubs.record-created-at-source-date 2018-12-08 en
pubs.dimensions-id 30523658 en


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