Impact of prematurity for pancreatic islet and beta-cell development.

Show simple item record Bloomfield, Francis en 2020-01-12T20:53:22Z en 2018-09 en
dc.identifier.issn 0022-0795 en
dc.identifier.uri en
dc.description.abstract As increasing numbers of babies born preterm survive into adulthood, it is becoming clear that, in addition to the well-described risks of neurodevelopmental sequelae, there also are increased risks for non-communicable diseases, including diabetes. Epidemiological studies indicate that risks are increased even for birth at late preterm and early term gestations and for both type 1 and type 2 diabetes. Thus, factors related to preterm birth likely affect development of the fetal and neonatal beta-cell in addition to effects on peripheral insulin sensitivity. These factors could operate prior to preterm birth and be related to the underlying cause of preterm birth, to the event of being born preterm itself, to the postnatal care of the preterm neonate or to a combination of these exposures. Experimental evidence indicates that factors may be operating during all these critical periods to contribute to altered development of beta-cell mass in those born preterm. Greater understanding of how these factors impact upon development of the pancreas may lead to interventions or management approaches that mitigate the increased risk of later diabetes. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries The Journal of endocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Islets of Langerhans en
dc.subject Humans en
dc.subject Premature Birth en
dc.subject Infant, Premature, Diseases en
dc.subject Diabetes Mellitus, Type 2 en
dc.subject Risk Factors en
dc.subject Pregnancy en
dc.subject Infant, Newborn en
dc.subject Infant, Premature en
dc.subject Female en
dc.subject Insulin-Secreting Cells en
dc.title Impact of prematurity for pancreatic islet and beta-cell development. en
dc.type Journal Article en
dc.identifier.doi 10.1530/joe-18-0021 en
pubs.issue 3 en
pubs.begin-page R161 en
pubs.volume 238 en
dc.rights.holder Copyright: The author en
pubs.end-page R171 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 752803 en Liggins Institute en LiFePATH en
dc.identifier.eissn 1479-6805 en
pubs.record-created-at-source-date 2018-06-14 en
pubs.dimensions-id 29895718 en

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