dc.contributor.author |
Anderson, Ngaire |
en |
dc.contributor.author |
De Laat, Monique |
en |
dc.contributor.author |
Benton, Samantha |
en |
dc.contributor.author |
von Dadelszen, Peter |
en |
dc.contributor.author |
McCowan, Lesley |
en |
dc.date.accessioned |
2020-01-12T20:53:41Z |
en |
dc.date.issued |
2019-02 |
en |
dc.identifier.citation |
The Australian & New Zealand journal of obstetrics & gynaecology 59(1):89-95 Feb 2019 |
en |
dc.identifier.issn |
0004-8666 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49506 |
en |
dc.description.abstract |
BACKGROUND:At-risk small-for-gestational age (SGA) pregnancies in New Zealand are identified using Doppler ultrasound; fetuses with Doppler abnormalities are considered growth restricted (FGR). Low maternal placental growth factor (PlGF) has also been associated with late-onset FGR. AIMS:To investigate whether low PlGF at diagnosis of late-onset SGA identifies the same fetuses classified FGR by detailed Doppler studies, and the association between low PlGF and adverse pregnancy outcomes. METHODS:Among an historical database of normotensive suspected SGA pregnancies (fetal abdominal circumference <10th percentile) ≥32 weeks gestation, the ability of low PlGF (<5th percentile) to identify FGR infants was investigated. 'Initial FGR' was an abnormal umbilical artery resistance index (RI) or estimated fetal weight <3rd customised centile. 'Secondary FGR' was abnormal internal carotid RI, cerebro-placental ratio and/or mean uterine artery RI. Development of hypertensive disease and adverse perinatal outcomes were compared by PlGF status. RESULTS:Of 136 SGA pregnancies, 56 (41.1%) had initial FGR. Of the remaining, 20 (25.0%) had secondary FGR, 17 (21.3%) low PlGF. The sensitivity of low PlGF identifying secondary FGR was 0.30 (95% CI 0.14-0.50), specificity 0.83 (0.70-0.92), positive predictive value 0.47 (0.23-0.72) and negative predictive value 0.70 (0.57-0.81). Overall, low PlGF occurred in 44/136 (32.4%) pregnancies and was associated with gestational hypertensive disease (63.6% vs 15.2%, P < 0.01), adverse perinatal outcome (34.1% vs 15.2%, P = 0.01) and very low birthweight (customised centile 2.2 vs 6.8, P < 0.01). CONCLUSIONS:At diagnosis of late-onset SGA, low PlGF was poor at identifying Doppler-defined FGR. Low PlGF identified pregnancies at risk of hypertensive disease, adverse perinatal outcome and very low birthweight. |
en |
dc.format.medium |
Print-Electronic |
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dc.language |
eng |
en |
dc.relation.ispartofseries |
The Australian & New Zealand journal of obstetrics & gynaecology |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html |
en |
dc.subject |
Humans |
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dc.subject |
Fetal Growth Retardation |
en |
dc.subject |
Prenatal Diagnosis |
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dc.subject |
Pregnancy Outcome |
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dc.subject |
Sensitivity and Specificity |
en |
dc.subject |
Predictive Value of Tests |
en |
dc.subject |
Pregnancy |
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dc.subject |
Pregnancy Trimester, Third |
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dc.subject |
Adult |
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dc.subject |
Infant, Newborn |
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dc.subject |
Infant, Small for Gestational Age |
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dc.subject |
New Zealand |
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dc.subject |
Female |
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dc.subject |
Biomarkers |
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dc.subject |
Placenta Growth Factor |
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dc.title |
Placental growth factor as an indicator of fetal growth restriction in late-onset small-for-gestational age pregnancies. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/ajo.12831 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
89 |
en |
pubs.volume |
59 |
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dc.rights.holder |
Copyright: The Royal Australian and New Zealand College of Obstetricians and Gynaecologists |
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pubs.end-page |
95 |
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pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Evaluation Study |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
744305 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1479-828X |
en |
pubs.record-created-at-source-date |
2018-06-01 |
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pubs.dimensions-id |
29851029 |
en |