dc.contributor.author |
Li, Fengxia |
en |
dc.contributor.author |
Liu, Karen |
en |
dc.contributor.author |
Gray, Clint |
en |
dc.contributor.author |
Harris, Paul |
en |
dc.contributor.author |
Reynolds, Clare |
en |
dc.contributor.author |
Vickers, Mark |
en |
dc.contributor.author |
Guan, Jian |
en |
dc.date.accessioned |
2020-01-12T22:24:52Z |
en |
dc.date.issued |
2020-02 |
en |
dc.identifier.issn |
0939-4753 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49530 |
en |
dc.description.abstract |
BACKGROUND AND AIMS:Insulin-like growth factor (IGF)-1 deficiency is associated with a range of metabolic disorders. Cyclic glycine-proline (cGP) is a natural nutrient and regulates the amount of active IGF-1 in plasma. Plasma cGP decreases in hypertensive women whereas increases in obese women, suggesting its involvement in cardio-metabolic function. We therefore examined the effects of cGP on metabolic profiles and blood pressure in high-fat diet (HFD)-induced obese male rats. METHODS:Male rats were fed either a HFD or a standard chow diet (STD) ad-libitum from 3 to 15 weeks of age. Rats were administered either saline or cGP from 11 to 15 weeks of age. At 14 weeks of age, systolic-blood pressure (SBP) was measured by tail-cuff plethysmography and body composition quantified by DEXA. Blood and retroperitoneal fat tissues were collected. Plasma concentrations of insulin, IGF-1, IGF binding protein (IGFBP)-3 and cGP were evaluated using ELISA and HPLC-MS respectively. RESULTS:Compared to STD, HFD feeding increased SBP, total fat mass and fat/lean ratio, retroperitoneal fat weight, fasting plasma insulin and cGP concentrations whereas decreased plasma IGF-1 and IGFBP-3 concentrations. Administration of cGP reduced SBP and retroperitoneal fat weight, but had no effect on body composition and plasma insulin concentrations. CONCLUSION:HFD-associated decreases in IGFBP-3 and increases in cGP represent an autocrine response to normalize IGF-1 function through improving the amount of bioavailable IGF-1 in the circulation of obese male rats. The beneficial effects of cGP on SBP and retroperitoneal fat mass may suggest a therapeutic potential for cGP in HFD-associated cardio-metabolic complications. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Nutrition, metabolism, and cardiovascular diseases : NMCD |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.numecd.2019.09.016 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
339 |
en |
pubs.volume |
30 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
346 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
788339 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1590-3729 |
en |
pubs.record-created-at-source-date |
2019-11-23 |
en |
pubs.dimensions-id |
31753784 |
en |