Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats.

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Show simple item record Li, Fengxia en Liu, Karen en Gray, Clint en Harris, Paul en Reynolds, Clare en Vickers, Mark en Guan, Jian en 2020-01-12T22:24:52Z en 2020-02 en
dc.identifier.issn 0939-4753 en
dc.identifier.uri en
dc.description.abstract BACKGROUND AND AIMS:Insulin-like growth factor (IGF)-1 deficiency is associated with a range of metabolic disorders. Cyclic glycine-proline (cGP) is a natural nutrient and regulates the amount of active IGF-1 in plasma. Plasma cGP decreases in hypertensive women whereas increases in obese women, suggesting its involvement in cardio-metabolic function. We therefore examined the effects of cGP on metabolic profiles and blood pressure in high-fat diet (HFD)-induced obese male rats. METHODS:Male rats were fed either a HFD or a standard chow diet (STD) ad-libitum from 3 to 15 weeks of age. Rats were administered either saline or cGP from 11 to 15 weeks of age. At 14 weeks of age, systolic-blood pressure (SBP) was measured by tail-cuff plethysmography and body composition quantified by DEXA. Blood and retroperitoneal fat tissues were collected. Plasma concentrations of insulin, IGF-1, IGF binding protein (IGFBP)-3 and cGP were evaluated using ELISA and HPLC-MS respectively. RESULTS:Compared to STD, HFD feeding increased SBP, total fat mass and fat/lean ratio, retroperitoneal fat weight, fasting plasma insulin and cGP concentrations whereas decreased plasma IGF-1 and IGFBP-3 concentrations. Administration of cGP reduced SBP and retroperitoneal fat weight, but had no effect on body composition and plasma insulin concentrations. CONCLUSION:HFD-associated decreases in IGFBP-3 and increases in cGP represent an autocrine response to normalize IGF-1 function through improving the amount of bioavailable IGF-1 in the circulation of obese male rats. The beneficial effects of cGP on SBP and retroperitoneal fat mass may suggest a therapeutic potential for cGP in HFD-associated cardio-metabolic complications. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Nutrition, metabolism, and cardiovascular diseases : NMCD en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.numecd.2019.09.016 en
pubs.issue 2 en
pubs.begin-page 339 en
pubs.volume 30 en
dc.rights.holder Copyright: The author en
pubs.end-page 346 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 788339 en Liggins Institute en Medical and Health Sciences en Medical Sciences en Pharmacology en Science en Biological Sciences en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1590-3729 en
pubs.record-created-at-source-date 2019-11-23 en
pubs.dimensions-id 31753784 en

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