Pharmacokinetics and Pharmacodynamics in the Pediatric Patient

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dc.contributor.author Anderson, Brian en
dc.contributor.editor Absalom, AR en
dc.contributor.editor Mason, KP en
dc.date.accessioned 2020-01-12T22:49:40Z en
dc.date.issued 2017 en
dc.identifier.isbn 9783319476094 en
dc.identifier.uri http://hdl.handle.net/2292/49598 en
dc.description.abstract The pharmacokinetics (PK), pharmacodynamics (PD) and side effect profile of most medications used in children differ from those in adults; these differences are most pronounced in neonates. PK are affected by maturation of organ function and body composition, altered protein binding, distinct disease spectrum, diverse behaviour and dissimilar receptor patterns (Kearns et al., N Engl J Med 349(12):1157–67, 2003). The capacity of the end organ, such as the brain, heart or skeletal muscle, to respond to medications may also differ in children compared with adults (PD effects). Dose modification to achieve the desired clinical response and avoid toxicity is required for children. Dose calculations are based on knowledge of PK and PD (Anderson and Holford, Arch Dis Child. 98(9):737–44, 2013). en
dc.publisher Springer en
dc.relation.ispartof Total Intravenous Anesthesia and Target Controlled Infusions en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Pharmacokinetics and Pharmacodynamics in the Pediatric Patient en
dc.type Book Item en
dc.identifier.doi 10.1007/978-3-319-47609-4_25 en
pubs.begin-page 441 en
dc.rights.holder Copyright: The author en
pubs.author-url https://books.google.co.nz/books?id=PLI-DgAAQBAJ en
pubs.end-page 516 en
pubs.place-of-publication New York, USA en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.elements-id 632969 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Anaesthesiology en
pubs.record-created-at-source-date 2017-06-28 en


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