Pharmacokinetics and Pharmacodynamics in the Pediatric Patient

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Show simple item record Anderson, Brian en
dc.contributor.editor Absalom, AR en
dc.contributor.editor Mason, KP en 2020-01-12T22:49:40Z en 2017 en
dc.identifier.isbn 9783319476094 en
dc.identifier.uri en
dc.description.abstract The pharmacokinetics (PK), pharmacodynamics (PD) and side effect profile of most medications used in children differ from those in adults; these differences are most pronounced in neonates. PK are affected by maturation of organ function and body composition, altered protein binding, distinct disease spectrum, diverse behaviour and dissimilar receptor patterns (Kearns et al., N Engl J Med 349(12):1157–67, 2003). The capacity of the end organ, such as the brain, heart or skeletal muscle, to respond to medications may also differ in children compared with adults (PD effects). Dose modification to achieve the desired clinical response and avoid toxicity is required for children. Dose calculations are based on knowledge of PK and PD (Anderson and Holford, Arch Dis Child. 98(9):737–44, 2013). en
dc.publisher Springer en
dc.relation.ispartof Total Intravenous Anesthesia and Target Controlled Infusions en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Pharmacokinetics and Pharmacodynamics in the Pediatric Patient en
dc.type Book Item en
dc.identifier.doi 10.1007/978-3-319-47609-4_25 en
pubs.begin-page 441 en
dc.rights.holder Copyright: The author en en
pubs.end-page 516 en New York, USA en
dc.rights.accessrights en
pubs.elements-id 632969 en Medical and Health Sciences en School of Medicine en Anaesthesiology en
pubs.record-created-at-source-date 2017-06-28 en

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