Developmental pharmacology

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Show simple item record Anderson, Brian en Peyton, J en Meakin, GH en
dc.contributor.editor Holzman, RS en
dc.contributor.editor Mancuso, TJ en
dc.contributor.editor Polaner, DM en 2020-01-12T22:50:06Z en 2016 en
dc.identifier.isbn 146988982X en
dc.identifier.isbn 9781469889825 en
dc.identifier.uri en
dc.description.abstract Children, especially infants, differ from adults in the way they respond to drugs. These differences became apparent in the 1950s following a number of adverse drug events, including fatal cardiovascular collapse in infants treated with chloramphenicol and an increase in kernicterus among newborns treated with sulfonamides. Pediatric responses to drugs are determined by a large number of factors that change independently of one another during growth and development. The factors determining pediatric responses to drugs can be divided into those affecting pharmacokinetics (what the body does to the drug) and those affecting pharmacodynamics (what the drug does to the body). The aim of this chapter is to review these factors and describe how they affect the pharmacology of selected anesthetic drugs in infants and children. en
dc.description.uri en
dc.publisher Wolters Kluwer en
dc.relation.ispartof A practical approach to pediatric anesthesia en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Developmental pharmacology en
dc.type Book Item en
pubs.begin-page 18 en
dc.rights.holder Copyright: The author en en
pubs.edition 2nd en
pubs.end-page 54 en Philadelphia, USA en
dc.rights.accessrights en
pubs.elements-id 512885 en Medical and Health Sciences en School of Medicine en Anaesthesiology en
pubs.number 2 en
pubs.record-created-at-source-date 2015-12-12 en

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