Total Intravenous Anesthesia and Target-Controlled Infusion

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dc.contributor.author Anderson, Brian en
dc.contributor.author Houghton, J en
dc.date.accessioned 2020-01-12T22:50:46Z en
dc.date.issued 2019-01-01 en
dc.identifier.isbn 9780323429740 en
dc.identifier.uri http://hdl.handle.net/2292/49603 en
dc.description.abstract © 2019 Elsevier Inc. All rights reserved. Total intravenous anesthesia (TIVA) is the use of intravenous agents for induction and maintenance of anesthesia. The most frequently used agent is propofol. Propofol effect is usually augmented with an opioid (e.g., remifentanil). Although it is possible to implement TIVA using pumps with the infusion rate controlled manually, the advent of pumps programed with pharmacokinetic information has facilitated use. The use of published pharmacokinetic parameter sets (referred to as models and often described by the principle author) allows the pump to determine infusion rates to maintain a certain plasma concentration (Cp) or effect site concentration (Ce). Covariate knowledge (e.g., weight, age) allows individualization of dose. There are limited data in the neonatal and infant populations. Common indications for TIVA techniques include children at risk for malignant hyperthermia, procedures with a high risk of postoperative nausea and vomiting, brief radiologic or painful procedures when rapid recovery is needed and frequent repeated anesthesia. However, use is spreading to other fields. Fears that children may develop propofol infusion syndrome during routine anesthesia have not eventuated. en
dc.relation.ispartof A Practice of Anesthesia for Infants and Children en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Total Intravenous Anesthesia and Target-Controlled Infusion en
dc.type Book Item en
dc.identifier.doi 10.1016/B978-0-323-42974-0.00008-2 en
pubs.begin-page 177 en
dc.rights.holder Copyright: The author en
pubs.end-page 198.e3 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.elements-id 754991 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Anaesthesiology en


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