Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity.

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dc.contributor.author Parveen, Shahida en
dc.contributor.author Hanif, Muhammad en
dc.contributor.author Leung, Yee Fun en
dc.contributor.author Tong, Ki en
dc.contributor.author Yang, Annie en
dc.contributor.author Astin, Jonathan en
dc.contributor.author De Zoysa, Gayan en
dc.contributor.author Steel, Tasha R en
dc.contributor.author Goodman, David en
dc.contributor.author Hanif, Muhammad en
dc.contributor.author Soehnel, Tilo en
dc.contributor.author Sarojini Amma, Vijayalekshmi en
dc.contributor.author Jamieson, Stephen en
dc.contributor.author Hartinger, Christian en
dc.date.accessioned 2020-01-12T22:56:07Z en
dc.date.issued 2019-10 en
dc.identifier.citation Chemical Communications 55(80):12016-12019 Oct 2019 en
dc.identifier.issn 1359-7345 en
dc.identifier.uri http://hdl.handle.net/2292/49615 en
dc.description.abstract Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear RhIII(Cp*) and IrIII(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investigational drug IT-139, while being less toxic in haemolysis and in vivo zebrafish models. The mode of action appears to be related to DNA damage and ROS-mediated stress pathways. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Chemical communications (Cambridge, England) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Cell Line, Tumor en
dc.subject Animals en
dc.subject Zebrafish en
dc.subject Humans en
dc.subject Mice en
dc.subject DNA Damage en
dc.subject Hemolysis en
dc.subject Cisplatin en
dc.subject Iridium en
dc.subject Rhodium en
dc.subject Ruthenium en
dc.subject Reactive Oxygen Species en
dc.subject Antineoplastic Agents en
dc.subject Ligands en
dc.subject Drug Screening Assays, Antitumor en
dc.subject Cell Survival en
dc.subject Structure-Activity Relationship en
dc.subject Oxidation-Reduction en
dc.subject Coordination Complexes en
dc.title Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity. en
dc.type Journal Article en
dc.identifier.doi 10.1039/c9cc03822a en
pubs.issue 80 en
pubs.begin-page 12016 en
pubs.volume 55 en
dc.rights.holder Copyright: The Royal Society of Chemistry 2019 en
pubs.end-page 12019 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 780855 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Pharmacology en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1364-548X en
pubs.record-created-at-source-date 2019-09-10 en
pubs.dimensions-id 31498360 en


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