Comparison of corneal biomechanical properties following penetrating keratoplasty and deep anterior lamellar keratoplasty for keratoconus.

Show simple item record Ziaei, Mohammed en Vellara, Hans R en Gokul, Akilesh en Ali, Noor Q en McGhee, Charles en Patel, Dipika en 2020-01-12T22:58:40Z en 2020-03 en
dc.identifier.issn 1442-6404 en
dc.identifier.uri en
dc.description.abstract IMPORTANCE:Keratoplasty is a surgical procedure to create a more regular optical surface following biomechanical weakening of the cornea in keratoconus. The ideal keratoplasty procedure should also restore corneal biomechanics to that of the healthy cornea. BACKGROUND:This study aimed to evaluate and compare the biomechanical properties of corneas following penetrating keratoplasty (PKP) and predescematic deep anterior lamellar keratoplasty (DALK) to those of healthy eyes. DESIGN:Prospective cross-sectional study. PARTICIPANTS:Two cohorts of post-keratoplasty eyes (42 eyes with PKP and 27 eyes with DALK) with each other, and with a cohort of 152 healthy eyes. METHODS:All eyes were examined by slit-lamp biomicroscopy, tomography, anterior segment-OCT and non-contact tonometry CorVis ST (CST). MAIN OUTCOME MEASURES:CST biomechanical parameters, maximum corneal deformation (MCD) and corneal energy dissipation were compared between keratoplasty techniques, and with healthy eyes. RESULTS:The mean age of participants with PKP and DALK were 35 ± 13.7 and 36.1 ± 12.6 years, respectively. None of the CST parameters were significantly different between PKP and DALK eyes. However, when compared to healthy corneas, numerous parameters were significantly different for both keratoplasty techniques. Of note, MCD was significantly higher in PKP compared to DALK and healthy corneas, after controlling for co-factors. CONCLUSIONS AND RELEVANCE:Neither type of keratoplasty technique utilized in keratoconus completely restored corneal biomechanical properties to that of healthy corneas. However, PKP resulted in a greater number of parameters significantly different to healthy corneas, compared to DALK. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Clinical & experimental ophthalmology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Comparison of corneal biomechanical properties following penetrating keratoplasty and deep anterior lamellar keratoplasty for keratoconus. en
dc.type Journal Article en
dc.identifier.doi 10.1111/ceo.13677 en
pubs.issue 2 en
pubs.begin-page 174 en
pubs.volume 48 en
dc.rights.holder Copyright: The author en
pubs.end-page 182 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.elements-id 786616 en Medical and Health Sciences en School of Medicine en Ophthalmology Department en
dc.identifier.eissn 1442-9071 en
pubs.record-created-at-source-date 2019-11-10 en
pubs.dimensions-id 31705767 en

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