dc.contributor.author |
Ziaei, Mohammed |
en |
dc.contributor.author |
Gokul, Akilesh |
en |
dc.contributor.author |
Vellara, Hans |
en |
dc.contributor.author |
Meyer, Jay |
en |
dc.contributor.author |
Patel, Dipika |
en |
dc.contributor.author |
McGhee, Charles |
en |
dc.date.accessioned |
2020-01-12T22:58:58Z |
en |
dc.date.issued |
2019-11 |
en |
dc.identifier.issn |
1442-6404 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49620 |
en |
dc.description.abstract |
IMPORTANCE:Keratoconus is a debilitating condition with a disproportionately high impact on health resources and vision-specific quality of life. BACKGROUND:This study aimed to compare 2-year outcomes of epithelium-off pulsed (p-ACXL) and epithelium-off continuous (c-ACXL) accelerated corneal crosslinking in progressive keratoconus. DESIGN:Prospective, interventional case series. PARTICIPANTS:Eighty eyes of 80 patients were included. METHODS:The visual, refractive and tomographic results of the two crosslinking protocols were compared. MAIN OUTCOME MEASURES:Uncorrected distance visual acuity, corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (MRSE) and maximum keratometry (KMAX ) on corneal tomography assessment. RESULTS:The mean patient age was 22.51 ± 6.12 years (SD) and 22.08 ± 5.72 years in the p-ACXL and c-ACXL groups, respectively. The mean CDVA significantly improved from 0.30 ± 0.16 logMAR at baseline to 0.23 ± 0.17 logMAR at 24 months (P = .04) in the p-ACXL group and from 0.36 ± 0.22 logMAR to 0.26 ± 0.27 logMAR (P = .02) in the c-ACXL group. The mean induced change in MRSE (+1.79 ± 2.30 D vs +0.27 ± 3.19 D, P = .04) and KMAX (-1.75 ± 1.80 D vs -0.39 ± 1.95 D, P = .04) were superior in the c-ACXL group compared to the p-ACXL group at 24 months. No complications were encountered. CONCLUSIONS AND RELEVANCE:In this prospective study, both p-ACXL and c-ACXL treatments were safe methods to halt the progression of keratoconus within a follow-up period of 24 months. c-ACXL appeared to offer superior refractive and tomographic outcomes when compared to p-ACXL but this did not translate into better visual outcomes. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Clinical & experimental ophthalmology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Prospective two-year study of clinical outcomes following epithelium-off pulsed versus continuous accelerated corneal crosslinking for keratoconus. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/ceo.13567 |
en |
pubs.issue |
8 |
en |
pubs.begin-page |
980 |
en |
pubs.volume |
47 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
986 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
775432 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1442-9071 |
en |
pubs.record-created-at-source-date |
2019-06-07 |
en |
pubs.dimensions-id |
31170327 |
en |