The Development and Decay of the Circadian Clock in Drosophila melanogaster

ResearchSpace Repository

Show simple item record Zhao, Jia en Warman, Guy en Cheeseman, James en 2020-01-12T22:59:11Z en 2019 en
dc.identifier.citation Clocks and Sleep 1(4):489-500 2019 en
dc.identifier.uri en
dc.description.abstract The way in which the circadian clock mechanism develops and decays throughout life is interesting for a number of reasons and may give us insight into the process of aging itself. The Drosophila model has been proven invaluable for the study of the circadian clock and development and aging. Here we review the evidence for how the Drosophila clock develops and changes throughout life, and present a new conceptual model based on the results of our recent work. Firefly luciferase lines faithfully report the output of known clock genes at the central clock level in the brain and peripherally throughout the whole body. Our results show that the clock is functioning in embryogenesis far earlier than previously thought. This central clock in the fly remains robust throughout the life of the animal and only degrades immediately prior to death. However, at the peripheral (non-central oscillator level) the clock shows weakened output as the animal ages, suggesting the possibility of the breakdown in the cohesion of the circadian network. en
dc.publisher MDPI en
dc.relation.ispartofseries Clocks and Sleep en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.title The Development and Decay of the Circadian Clock in Drosophila melanogaster en
dc.type Journal Article en
dc.identifier.doi 10.3390/clockssleep1040037 en
pubs.issue 4 en
pubs.begin-page 489 en
pubs.volume 1 en
dc.rights.holder Copyright: The authors en
pubs.end-page 500 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 786499 en
dc.relation.isnodouble 1352187 * Medical and Health Sciences en School of Medicine en Anaesthesiology en
dc.identifier.eissn 2624-5175 en
pubs.record-created-at-source-date 2019-11-21 en 2019-11-19 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record Except where otherwise noted, this item's license is described as


Search ResearchSpace

Advanced Search