Effects of arm weight support on neuromuscular activation during reaching in chronic stroke patients.

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dc.contributor.author Runnalls, Keith D en
dc.contributor.author Ortega-Auriol, Pablo en
dc.contributor.author McMorland, Angus en
dc.contributor.author Anson, James en
dc.contributor.author Byblow, Winston en
dc.date.accessioned 2020-01-12T23:02:46Z en
dc.date.issued 2019-12 en
dc.identifier.issn 0014-4819 en
dc.identifier.uri http://hdl.handle.net/2292/49628 en
dc.description.abstract To better understand how arm weight support (WS) can be used to alleviate upper limb impairment after stroke, we investigated the effects of WS on muscle activity, muscle synergy expression, and corticomotor excitability (CME) in 13 chronic stroke patients and 6 age-similar healthy controls. For patients, lesion location and corticospinal tract integrity were assessed using magnetic resonance imaging. Upper limb impairment was assessed using the Fugl-Meyer upper extremity assessment with patients categorised as either mild or moderate-severe. Three levels of WS were examined: low = 0, medium = 50 and high = 100% of full support. Surface EMG was recorded from 8 upper limb muscles, and muscle synergies were decomposed using non-negative matrix factorisation from data obtained during reaching movements to an array of 14 targets using the paretic or dominant arm. Interactions between impairment level and WS were found for the number of targets hit, and EMG measures. Overall, greater WS resulted in lower EMG levels, although the degree of modulation between WS levels was less for patients with moderate-severe compared to mild impairment. Healthy controls expressed more synergies than patients with moderate-severe impairment. Healthy controls and patients with mild impairment showed more synergies with high compared to low weight support. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) to which stimulus-response curves were fitted as a measure of corticomotor excitability (CME). The effect of WS on CME varied between muscles and across impairment level. These preliminary findings demonstrate that WS has direct and indirect effects on muscle activity, synergies, and CME and warrants further study in order to reduce upper limb impairment after stroke. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Experimental brain research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Arm en
dc.subject Muscle, Skeletal en
dc.subject Motor Cortex en
dc.subject Humans en
dc.subject Chronic Disease en
dc.subject Electromyography en
dc.subject Severity of Illness Index en
dc.subject Motor Activity en
dc.subject Evoked Potentials, Motor en
dc.subject Posture en
dc.subject Weight-Bearing en
dc.subject Aged en
dc.subject Aged, 80 and over en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.subject Transcranial Magnetic Stimulation en
dc.subject Stroke en
dc.title Effects of arm weight support on neuromuscular activation during reaching in chronic stroke patients. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s00221-019-05687-9 en
pubs.issue 12 en
pubs.begin-page 3391 en
pubs.volume 237 en
dc.rights.holder Copyright: The author en
pubs.end-page 3408 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 787968 en
pubs.org-id Science en
pubs.org-id Exercise Sciences en
dc.identifier.eissn 1432-1106 en
pubs.record-created-at-source-date 2019-11-16 en
pubs.dimensions-id 31728596 en


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