Characterization of the bioactivities of an ethanol extract and some of its constituents from the New Zealand native mushroom Hericium novae-zealandiae.

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dc.contributor.author Chen, Zhixia en
dc.contributor.author Bishop, Karen en
dc.contributor.author Tanambell, Hartono en
dc.contributor.author Buchanan, Peter en
dc.contributor.author Smith, Chris en
dc.contributor.author Quek, Siew-Young en
dc.date.accessioned 2020-01-12T23:02:58Z en
dc.date.issued 2019-10 en
dc.identifier.issn 2042-6496 en
dc.identifier.uri http://hdl.handle.net/2292/49629 en
dc.description.abstract In this study, we investigated the potential bioactivities of an ethanol extract of Hericium novae-zealandiae and four of its constituents, namely hericenone C, hericene B, ergosterol and ergosterol peroxide. The proliferation of three prostate cancer cell lines, namely DU145, LNCaP and PC3, was evaluated after treatment with the extract and constituents. It was found that both the ethanol extract and ergosterol peroxide possess anti-proliferative activities to the three prostate cancer cell lines. Ergosterol peroxide was considered likely to be one of the major compounds responsible for the anti-proliferative effect of the ethanol extract. Subsequently, the results of RT-qPCR assay showed two possible mechanisms for these anti-proliferative activities. One is apoptosis, supported by the up-regulation of CASP3, CASP8, CASP9, and an increase in the ratio of Bax/Bcl2. The other is anti-inflammation, indicated by the down-regulation of IL6 and up-regulation of IL24. The ethanol extract also exhibited antioxidant and AChE inhibitory (though weak) activities. However, none of the four compounds were found to account for these latter two activities. This is the first report of the bioactivities, and the corresponding active ingredients of lipophilic constituents from H. novae-zealandiae. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Food & function en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Characterization of the bioactivities of an ethanol extract and some of its constituents from the New Zealand native mushroom Hericium novae-zealandiae. en
dc.type Journal Article en
dc.identifier.doi 10.1039/c9fo01672d en
pubs.issue 10 en
pubs.begin-page 6633 en
pubs.volume 10 en
dc.rights.holder Copyright: The author en
pubs.end-page 6643 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 783316 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Science en
pubs.org-id Chemistry en
dc.identifier.eissn 2042-650X en
pubs.record-created-at-source-date 2019-09-27 en
pubs.dimensions-id 31555775 en


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