dc.contributor.author |
McKeage, James |
en |
dc.contributor.author |
Ruddy, Bryan |
en |
dc.contributor.author |
Nielsen, Poul |
en |
dc.contributor.author |
Taberner, Andrew |
en |
dc.date.accessioned |
2020-01-12T23:14:53Z |
en |
dc.date.issued |
2018-12 |
en |
dc.identifier.issn |
1873-4995 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49640 |
en |
dc.description.abstract |
We present a new mechanism for achieving needle free jet injection that significantly reduces the power required to perform a given injection. Our 'compound ampoule' produces two phases of jet speed under a constant force input by changing the effective piston area part-way through the injection. In this paper we define the benefits associated with a compound ampoule, relative to those of the conventional single piston design, by developing expressions for the power and energy required to perform an injection. We demonstrate that a compound ampoule can reduce the maximum input power required to perform a jet injection to less than one fifth of that previously required, enabling motors of less than half the mass to perform the same injection. We then detail the development of a prototype compound ampoule injector. Results from testing of this prototype demonstrate the function of a compound ampoule and verify the expected reduction in the required power and energy. Injections into post mortem porcine tissue confirm that our compound ampoule prototype can achieve the delivery of 1 mL of liquid into post-mortem tissue at least as effectively as a conventional ampoule. This approach will advance progress toward light-weight and power-efficient needle-free jet injectors for transdermal drug delivery. |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Journal of Controlled Release |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Power-efficient controlled jet injection using a compound ampoule |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.jconrel.2018.10.025 |
en |
pubs.begin-page |
127 |
en |
pubs.volume |
291 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
134 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
755325 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2018-10-29 |
en |
pubs.dimensions-id |
30359666 |
en |