Power-efficient controlled jet injection using a compound ampoule

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dc.contributor.author McKeage, James en
dc.contributor.author Ruddy, Bryan en
dc.contributor.author Nielsen, Poul en
dc.contributor.author Taberner, Andrew en
dc.date.accessioned 2020-01-12T23:14:53Z en
dc.date.issued 2018-12 en
dc.identifier.issn 1873-4995 en
dc.identifier.uri http://hdl.handle.net/2292/49640 en
dc.description.abstract We present a new mechanism for achieving needle free jet injection that significantly reduces the power required to perform a given injection. Our 'compound ampoule' produces two phases of jet speed under a constant force input by changing the effective piston area part-way through the injection. In this paper we define the benefits associated with a compound ampoule, relative to those of the conventional single piston design, by developing expressions for the power and energy required to perform an injection. We demonstrate that a compound ampoule can reduce the maximum input power required to perform a jet injection to less than one fifth of that previously required, enabling motors of less than half the mass to perform the same injection. We then detail the development of a prototype compound ampoule injector. Results from testing of this prototype demonstrate the function of a compound ampoule and verify the expected reduction in the required power and energy. Injections into post mortem porcine tissue confirm that our compound ampoule prototype can achieve the delivery of 1 mL of liquid into post-mortem tissue at least as effectively as a conventional ampoule. This approach will advance progress toward light-weight and power-efficient needle-free jet injectors for transdermal drug delivery. en
dc.publisher Elsevier en
dc.relation.ispartofseries Journal of Controlled Release en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Power-efficient controlled jet injection using a compound ampoule en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jconrel.2018.10.025 en
pubs.begin-page 127 en
pubs.volume 291 en
dc.rights.holder Copyright: The author en
pubs.end-page 134 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 755325 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2018-10-29 en
pubs.dimensions-id 30359666 en


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