The effect of jet speed on large volume jet injection.

ResearchSpace/Manakin Repository

Show simple item record McKeage, James en Ruddy, Bryan en Nielsen, Poul en Taberner, Andrew en 2020-01-12T23:15:06Z en 2018-06 en
dc.identifier.citation Journal of controlled release, 280:51-57 Jun 2018 en
dc.identifier.issn 0168-3659 en
dc.identifier.uri en
dc.description.abstract Jet injection presents a promising alternative to needle and syringe injection for transdermal drug delivery. The controllability of recently-developed jet injection devices now allows jet speed to be modulated during delivery, and has enabled efficient and accurate delivery of volumes up to 0.3 mL. However, recent attempts to inject larger volumes of up to 1 mL using the same methods have highlighted the different requirements for successful delivery at these larger volumes. This study aims to establish the jet speed requirements for delivery of 1 mL of liquid using a controllable, voice coil driven injection device. Additionally, the effectiveness of a two-phase jet speed profile is explored (where jet speed is deliberately decreased toward the end of the injection) and compared to the constant jet speed case. A controllable jet injection device was developed to deliver volumes of 1 mL of liquid at jet speeds >140 m/s. This device was used to deliver a series of injections into post-mortem porcine tissue in single and two-phase jet speed profiles. Single-phase injections were performed over the range 80 m/s to 140 m/s. Consistent delivery success (>80% of the liquid delivered) was observed at a jet speed of 130 m/s or greater. Consistent penetration into the muscle layer coincided with delivery success. Two-phase injections of 1 mL were performed with a first phase volume of 0.15 mL, delivered at 140 m/s, while the injection of the remainder of fluid was delivered at a second phase speed that was varied over the range 60 m/s to 120 m/s. Ten two-phase injections were performed with a second phase speed of 100 m/s producing a mean delivery volume of 0.8 mL ± 0.2 mL, while the single-phase injections at 100 m/s achieved a mean delivery volume of 0.4 mL ± 0.3 mL. These results demonstrate that a reduced jet speed can be used in the later stages of a 1 mL injection to achieve delivery success at a reduced energy cost. We found that a jet speed approaching 100 m/s was required following initial penetration to successfully deliver 1 mL, whereas speeds as low as 50 m/s have been used for volumes of <0.3 mL. These findings provide valuable insight into the effect of injection volume and speed on delivery success; this information is particularly useful for devices that have the ability to vary jet speed during drug delivery. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Journal of controlled release : official journal of the Controlled Release Society en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Muscles en
dc.subject Skin en
dc.subject Animals en
dc.subject Swine en
dc.subject Pharmaceutical Preparations en
dc.subject Drug Delivery Systems en
dc.subject Administration, Cutaneous en
dc.subject Injections, Jet en
dc.subject Equipment Design en
dc.subject Permeability en
dc.subject Time Factors en
dc.title The effect of jet speed on large volume jet injection. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jconrel.2018.04.054 en
pubs.begin-page 51 en
pubs.volume 280 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 29723614 en
pubs.end-page 57 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 739502 en Bioengineering Institute en ABI Associates en Engineering en Engineering Science en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1873-4995 en
pubs.record-created-at-source-date 2018-05-04 en
pubs.dimensions-id 29723614 en

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