Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia

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dc.contributor.author Chiang, Samuel en
dc.contributor.author Chen,, TL en
dc.contributor.author Phillips, John en
dc.date.accessioned 2020-01-13T00:00:04Z en
dc.date.issued 2018-10-01 en
dc.identifier.citation Investigative ophthalmology & visual science 59(12):5188-5193 Oct 2018 en
dc.identifier.issn 0146-0404 en
dc.identifier.uri http://hdl.handle.net/2292/49650 en
dc.description.abstract Purpose: To investigate changes in subfoveal choroidal thickness (SFCT) induced by retinal defocus in presbyopic adults. Methods: Thirty-seven healthy presbyopic subjects (age 57.74±4.06 years) with low refractive errors (+ 0.08±1.09 Diopters [D]) viewed a distant target (video movie at 6 m) for 60 minutes on two occasions while SFCT was monitored with optical coherence tomography every 20 minutes. On each occasion, both eyes were optimally corrected for distance: one eye acted as control, while the other (experimental) eye viewed through an additional ophthalmic lens: a+ 2.00 D lens imposing myopic defocus on one occasion and a− 2.00 D lens imposing hyperopic defocus on the other occasion. Results: Baseline SFCT was not different between experimental and control eyes (226±72 μm vs. 232±75 μm; P= 0.28). Myopic defocus caused a significant (P< 0.001) increase in SFCT in the defocused eye by 20 minutes (and+ 10±5-μm increase at 60 minutes: P< 0.001), while hyperopic defocus caused a significant decrease in SFCT by 20 minutes (and− 10±5-μm decrease at 60 minutes: P< 0.001) with no change in control eyes. Conclusions: In presbyopic subjects, imposed myopic retinal defocus caused thickening of SFCT, while hyperopic defocus caused thinning of SFCT. This implies that uncorrected presbyopia, which is associated with hyperopic retinal defocus for near objects and which is highly prevalent in the developing world, would likely be associated with choroidal thinning and possibly reduced choroidal blood flow with prolonged periods in a near visual environment. en
dc.publisher Association for Research in Vision and Ophthalmology en
dc.relation.ispartofseries Investigative Ophthalmology & Visual Science en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.title Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia en
dc.type Journal Article en
dc.identifier.doi 10.1167/iovs.18-24815 en
pubs.issue 12 en
pubs.begin-page 5188 en
pubs.volume 59 en
dc.rights.holder Copyright: The authors en
pubs.author-url https://iovs.arvojournals.org/article.aspx?articleid=2711345 en
pubs.end-page 5193 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 755586 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Optometry and Vision Science en
pubs.record-created-at-source-date 2018-11-04 en
pubs.online-publication-date 2018-10-01 en
pubs.dimensions-id 30372745 en

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