Dietary intake influences gut microbiota development of healthy Australian children from the age of one to two years.

Show simple item record Matsuyama, Misa en Morrison, Mark en Cao, Kim-Anh Lê en Pruilh, Solange en Davies, Peter SW en Wall, Clare en Lovell, Amy en Hill, Rebecca J en 2020-02-11T03:40:31Z en 2019-08-28 en
dc.identifier.citation Scientific reports 9(1):12476 28 Aug 2019 en
dc.identifier.issn 2045-2322 en
dc.identifier.uri en
dc.description.abstract Early life nutrition is a vital determinant of an individual's life-long health and also directly influences the ecological and functional development of the gut microbiota. However, there are limited longitudinal studies examining the effect of diet on the gut microbiota development in early childhood. Here, up to seven stool samples were collected from each of 48 healthy children during their second year of life, and microbiota dynamics were assessed using 16S rRNA gene amplicon sequencing. Children's dietary information was also collected during the same period using a validated food frequency questionnaire designed for this age group, over five time points. We observed significant changes in gut microbiota community, concordant with changes in the children's dietary pattern over the 12-month period. In particular, we found differential effects on specific Firmicutes-affiliated lineages in response to frequent intake of either processed or unprocessed foods. Additionally, the consumption of fortified milk supplemented with a Bifidobacterium probiotic and prebiotics (synbiotics) further increased the presence of Bifidobacterium spp., highlighting the potential use of synbiotics to prolong and sustain changes in these lineages and shaping the gut microbiota community in young children. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Scientific reports en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.title Dietary intake influences gut microbiota development of healthy Australian children from the age of one to two years. en
dc.type Journal Article en
dc.identifier.doi 10.1038/s41598-019-48658-4 en
pubs.issue 1 en
pubs.begin-page 12476 en
pubs.volume 9 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 781036 en Medical and Health Sciences en Medical Sciences en Nutrition en
dc.identifier.eissn 2045-2322 en
pubs.record-created-at-source-date 2019-08-30 en
pubs.dimensions-id 31462648 en

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