dc.contributor.author |
Tottman, Anna |
en |
dc.contributor.author |
Bloomfield, Francis |
en |
dc.contributor.author |
Cormack, Barbara |
en |
dc.contributor.author |
Harding, Jane |
en |
dc.contributor.author |
Taylor, Janice |
en |
dc.contributor.author |
Alsweiler, Jane |
en |
dc.date.accessioned |
2020-02-11T23:28:22Z |
en |
dc.date.issued |
2020-04 |
en |
dc.identifier.citation |
Pediatric research 87(5):872-878 Apr 2020 |
|
dc.identifier.issn |
0031-3998 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49933 |
en |
dc.description.abstract |
BACKGROUND:Although early nutrition is associated with neurodevelopmental outcome at 2 years' corrected age in children born very preterm, it is not clear if these associations are different in girls and boys. METHODS:Retrospective cohort study of infants born <30 weeks' gestational age or <1500 g birth weight in Auckland, NZ. Macronutrient, energy and fluid volumes per kg per day were calculated from daily nutritional intakes and averaged over days 1-7 (week 1) and 1-28 (month 1). Primary outcome was survival without neurodevelopmental impairment at 2 years corrected age. RESULTS:More girls (215/478) survived without neurodevelopmental impairment at 2 years (82% vs. 72%, P = 0.02). Overall, survival without neurodevelopmental impairment was positively associated with more energy, fat, and enteral feeds in week 1, and more energy and enteral feeds in month 1 (P = 0.005-0.03), but all with sex interactions (P = 0.008-0.02). In girls but not boys, survival without neurodevelopmental impairment was positively associated with week 1 total intakes of fat (OR(95% CI) for highest vs. lowest intake quartile 62.6(6.6-1618.1), P < 0.001), energy (22.9(2.6-542.0), P = 0.03) and enteral feeds (1.9 × 109(9.5-not estimable), P < 0.001). CONCLUSIONS:Higher early fat and enteral feed intakes are associated with improved outcome in girls, but not boys. Future research should determine sex-specific neonatal nutritional requirements. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Pediatric research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://www.nature.com/nature-portfolio/editorial-policies/self-archiving-and-license-to-publish#AAMtermsV1 |
|
dc.title |
Sex-specific relationships between early nutrition and neurodevelopment in preterm infants. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1038/s41390-019-0695-y |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
872 |
en |
pubs.volume |
87 |
en |
dc.rights.holder |
Copyright: The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc |
en |
pubs.end-page |
878 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
790141 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
LiFePATH |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
en |
dc.identifier.eissn |
1530-0447 |
en |
pubs.record-created-at-source-date |
2019-11-30 |
en |
pubs.dimensions-id |
31783398 |
en |