Analysis of common cytogenetic abnormalities in New Zealand pediatric ALL shows ethnically diverse carriage of ETV6-RUNX1, without a corresponding difference in survival.

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dc.contributor.author Pettit, Tristan en
dc.contributor.author Cole, Nyree en
dc.contributor.author Leung, Wingchi en
dc.contributor.author Ballantine, Kirsten en
dc.contributor.author Macfarlane, Scott en
dc.date.accessioned 2020-02-11T23:28:30Z en
dc.date.issued 2017-12 en
dc.identifier.issn 1545-5009 en
dc.identifier.uri http://hdl.handle.net/2292/49935 en
dc.description.abstract The frequency of common cytogenetic abnormalities in pediatric acute lymphoblastic leukemia (ALL) is known to vary by geographic location and ethnic origin. This study aimed to determine the frequency of hypodiploidy, ETV6-RUNX1, BCR-ABL1, and MLL rearrangement within New Zealand's pediatric ALL population and to assess whether the frequency of these ALL prognostic markers varies according to ethnicity.The New Zealand Children's Cancer Registry provided information for all registered pediatric ALL patients that were diagnosed between 2000 and 2009, with medical records available for 246 patients. Each patient's medical record was reviewed to determine the frequency of hypodiploidy, ETV6-RUNX1, BCR-ABL1, MLL rearrangement, and cell lineage. Chi-square tests for independence were undertaken to compare the frequencies of cytogenetic abnormalities according to prioritized ethnicity.The frequency of cytogenetic ALL abnormalities in the New Zealand pediatric population were consistent with international reference values. A low frequency of ETV6-RUNX1 was evident for Maori pediatric ALL patients (5.4%, P = 0.018), when compared to Pacific peoples (21.1%) and non-Maori/non-Pacific peoples (27.4%). This has not impacted on outcome, however, with equivalent 5-year overall survival being observed in Maori (89.4%) compared to Pacific peoples (92.0%) and non-Maori/non-Pacific peoples (90.2%).A lower frequency of the favorable prognostic marker ETV6-RUNX1 was observed in Maori pediatric ALL patients. This did not translate into poorer survival. Future research into biological and nonbiological prognostic factors in this patient population may assist in explaining this finding. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Pediatric blood & cancer en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Chromosome Aberrations en
dc.subject Oncogene Proteins, Fusion en
dc.subject Adolescent en
dc.subject Child en
dc.subject Child, Preschool en
dc.subject Infant en
dc.subject Infant, Newborn en
dc.subject Female en
dc.subject Male en
dc.subject Core Binding Factor Alpha 2 Subunit en
dc.subject Leukemia, Lymphocytic, Chronic, B-Cell en
dc.title Analysis of common cytogenetic abnormalities in New Zealand pediatric ALL shows ethnically diverse carriage of ETV6-RUNX1, without a corresponding difference in survival. en
dc.type Journal Article en
dc.identifier.doi 10.1002/pbc.26676 en
pubs.issue 12 en
pubs.volume 64 en
dc.rights.holder Copyright: The author en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 792762 en
dc.identifier.eissn 1545-5017 en
pubs.record-created-at-source-date 2017-06-09 en
pubs.dimensions-id 28598545 en


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