dc.contributor.author |
Bulloch, Elizabeth |
en |
dc.contributor.author |
Lovell, Amy |
en |
dc.contributor.author |
Jordan-Cole, Vanessa |
en |
dc.contributor.author |
McCowan, Lesley |
en |
dc.contributor.author |
Thompson, John |
en |
dc.contributor.author |
Wall, Clare |
en |
dc.date.accessioned |
2020-02-11T23:28:33Z |
en |
dc.date.issued |
2018-07 |
en |
dc.identifier.issn |
0269-5022 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/49936 |
en |
dc.description.abstract |
BACKGROUND:Preeclampsia is a significant contributor to maternal and neonatal morbidity and mortality. Folic acid supplementation is recommended periconceptionally for the prevention of neural tube defects. Epidemiological evidence suggests that maternal folic acid supplementation may play a role in preventing other adverse birth outcomes. This systematic review aimed to investigate the effect of maternal folic acid supplementation during pregnancy on risk of preeclampsia and gestational hypertension. METHODS:Multiple scientific databases and grey literature were searched for relevant studies. Studies were reviewed according to pre-specified inclusion and exclusion criteria. Study characteristics were summarised and study quality was assessed. A meta-analysis of observational studies was conducted to examine the effect of maternal folic acid supplementation on preeclampsia risk. RESULTS:Meta-analysis of eight observational studies showed significantly lower odds of preeclampsia with folic acid supplementation in comparison to no folic acid supplementation: OR = 0.78 (95% CI 0.63, 0.98), with moderately high heterogeneity between studies. Subgroup analysis showed no significant subgroup difference between folic acid supplementation taken by itself, in comparison to folic acid taken in or alongside a multivitamin. CONCLUSION:Low level evidence is available for a modest association between maternal folic acid supplementation and reduction in preeclampsia risk. Future studies should differentiate between early and late onset and mild vs severe preeclampsia, and should control for relevant confounders including the presence of multivitamin supplements. The protocol for this systematic review was prospectively registered with PROSPERO (CRD42015029310). |
en |
dc.format.medium |
Print-Electronic |
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dc.language |
eng |
en |
dc.relation.ispartofseries |
Paediatric and perinatal epidemiology |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
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dc.subject |
Pregnancy Complications |
en |
dc.subject |
Pre-Eclampsia |
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dc.subject |
Folic Acid |
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dc.subject |
Pregnancy Outcome |
en |
dc.subject |
Evidence-Based Medicine |
en |
dc.subject |
Pregnancy |
en |
dc.subject |
Dietary Supplements |
en |
dc.subject |
Female |
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dc.title |
Maternal folic acid supplementation for the prevention of preeclampsia: A systematic review and meta-analysis. |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1111/ppe.12476 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
346 |
en |
pubs.volume |
32 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
357 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Meta-Analysis |
en |
pubs.subtype |
Systematic Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
744296 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Nutrition |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.org-id |
Paediatrics Child & Youth Hlth |
en |
dc.identifier.eissn |
1365-3016 |
en |
pubs.record-created-at-source-date |
2018-06-09 |
en |
pubs.dimensions-id |
29882975 |
en |