Comparison of the Acute Postprandial Circulating B-Vitamin and Vitamer Responses to Single Breakfast Meals in Young and Older Individuals: Preliminary Secondary Outcomes of a Randomized Controlled Trial.

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dc.contributor.author Sharma, Pankaja en
dc.contributor.author Gillies, Nicola en
dc.contributor.author Pundir, Shikha en
dc.contributor.author Pileggi, Chantal A en
dc.contributor.author Markworth, James F en
dc.contributor.author Thorstensen, Eric en
dc.contributor.author Cameron-Smith, David en
dc.contributor.author Milan, Amber en
dc.date.accessioned 2020-02-12T23:31:31Z en
dc.date.issued 2019-11-28 en
dc.identifier.citation Nutrients 11(12) 28 Nov 2019 en
dc.identifier.issn 2072-6643 en
dc.identifier.uri http://hdl.handle.net/2292/49942 en
dc.description.abstract B-vitamin deficiency is common in ageing populations either due to altered dietary habits or altered digestive and metabolic functions. There is limited data on the acute circulating concentrations of B-vitamins and their various forms (vitamers), following ingestion of realistic meals. This study compared the acute circulating B-vitamin and vitamer responses to either an energy-dense (ED) or a nutrient-dense (ND) breakfast meal, consumed in a randomized cross-over sequence, in older and younger adults (n = 15 and 15, aged 67.3 ± 1.5 and 22.7 ± 0.5 years (mean ± SEM), respectively). Eleven differing B-vitamins and vitamers were determined in plasma samples by ultra-high-performance liquid chromatography-tandem mass spectrometry, in the fasting and postprandial state (hourly for 5 h). While postprandial thiamine concentration increased following both meals, riboflavin increased only following a ND meal in both age groups. Many vitamins including nicotinic acid, pantothenic acid, pyridoxal, pyridoxamine, pyridoxal-5'phosphate, and 4-pyridoxic acid remained unaltered, and flavin mononucleotide (FMN), nicotinamide and nicotinuric acid concentrations reduced following both meals. Biological age and food composition had minimal impact on postprandial B-vitamin concentrations, yet the differences between the ED and ND meals for riboflavin highlight the importance of riboflavin intake to achieve adequacy. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries Nutrients en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Humans en
dc.subject Vitamin B Complex en
dc.subject Cross-Over Studies en
dc.subject Energy Intake en
dc.subject Aging en
dc.subject Postprandial Period en
dc.subject Breakfast en
dc.subject Nutrients en
dc.title Comparison of the Acute Postprandial Circulating B-Vitamin and Vitamer Responses to Single Breakfast Meals in Young and Older Individuals: Preliminary Secondary Outcomes of a Randomized Controlled Trial. en
dc.type Journal Article en
dc.identifier.doi 10.3390/nu11122893 en
pubs.issue 12 en
pubs.volume 11 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype research-article en
pubs.subtype Randomized Controlled Trial en
pubs.subtype Journal Article en
pubs.elements-id 788967 en
pubs.org-id Academic Services en
pubs.org-id Examinations en
pubs.org-id Liggins Institute en
dc.identifier.eissn 2072-6643 en
pubs.record-created-at-source-date 2019-12-05 en
pubs.dimensions-id 31795162 en


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