Cell wall-anchored 5'-nucleotidases in Gram-positive cocci.

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dc.contributor.author Soh, Kar Yan en
dc.contributor.author Hughes, Jacelyn en
dc.contributor.author Proft, Thomas en
dc.date.accessioned 2020-02-12T23:32:06Z en
dc.date.issued 2020-04 en
dc.identifier.issn 0950-382X en
dc.identifier.uri http://hdl.handle.net/2292/49951 en
dc.description.abstract 5'-nucleotidases (5'-NTs) are enzymes that catalyze the hydrolysis of nucleoside monophosphates to produce nucleosides and phosphate. Since the identification of adenosine synthase A (AdsA) in Staphylococcus aureus in 2009, several other 5'-NTs have been discovered in Gram-positive cocci, mainly in streptococci. Despite some differences in substrate specificity, pH range and metal ion requirements, all characterized 5'-NTs use AMP and ADP, and in some cases ATP, to produce the immunosuppressive adenosine, which dampens pro-inflammatory immune responses. Several 5'-NTs are also able to use dAMP as substrate to generate deoxy-adenosine which is cytotoxic for macrophages. A synergy between 5'-NTs and exonucleases which are commonly expressed in Gram-positive cocci has been described, where the nucleases provide dAMP as a cleavage product from DNA. Some of these nucleases produce dAMP by degrading the DNA backbone of neutrophil extracellular traps (NETs) resulting in a "double hit" strategy of immune evasion. This Micro Review provides an overview of the biochemical properties of Gram-positive cell wall-anchored 5'-NTs and their role as virulence factors. A potential use of 5'-NTs for vaccine development is also briefly discussed. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Molecular microbiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Cell wall-anchored 5'-nucleotidases in Gram-positive cocci. en
dc.type Journal Article en
dc.identifier.doi 10.1111/mmi.14442 en
pubs.issue 4 en
pubs.begin-page 691 en
pubs.volume 113 en
dc.rights.holder Copyright: The author en
pubs.end-page 698 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 790677 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Molecular Medicine en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1365-2958 en
pubs.record-created-at-source-date 2019-12-25 en
pubs.dimensions-id 31872460 en

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