Analysis of the Postoperative Periarticular Environment and Influence on Sustained Drug Delivery From a Gel Formulation.

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Show simple item record Svirskis, Darren en Martis, Waldron en Bhusal, Prabhat en Sharma, Manisha en Stowers, Renus en Young, Simon en 2020-02-13T03:00:02Z en 2018-09 en
dc.identifier.issn 0022-3549 en
dc.identifier.uri en
dc.description.abstract Regional intraarticular delivery of local anesthetics is effective in treating postoperative pain following total knee or hip replacement. Recent research efforts have been only partially successful in achieving sustained release of the analgesic agent, in part due to limited understanding of the biological environment into which these formulations are administered. This study aimed to detail the composition and properties of postoperative periarticular fluid (PO-PAF). PO-PAF was collected from 8 patients, and the composition and physicochemical properties were determined. A number of components were identified which are lacking from phosphate buffered saline (PBS) or other synthetic media. The differences in composition led to variation in the physicochemical properties of PO-PAF compared with PBS. Notably, significantly lower surface tension (p <0.05) and higher buffer capacity (p <0.05) were observed in the biological fluid. We demonstrated that the solubility of lidocaine is almost double in PO-PAF compared to PBS (p <0.05) and that lidocaine release from a poloxamer gelling system occurred faster into PO-PAF under both sink and nonsink conditions. Collectively, these data indicate PBS is inappropriate for the in vitro evaluation of intraarticular drug delivery systems. The presented data describe that PO-PAF and will support the future development of biorelevant media to ultimately improve in vivo-in vitro correlation. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Journal of pharmaceutical sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Cartilage, Articular en
dc.subject Joint Capsule en
dc.subject Humans en
dc.subject Osteoarthritis, Knee en
dc.subject Osteoarthritis, Hip en
dc.subject Pain, Postoperative en
dc.subject Gels en
dc.subject Delayed-Action Preparations en
dc.subject Drug Delivery Systems en
dc.subject Injections, Intra-Articular en
dc.subject Drug Compounding en
dc.subject Adult en
dc.subject Aged en
dc.subject Aged, 80 and over en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.title Analysis of the Postoperative Periarticular Environment and Influence on Sustained Drug Delivery From a Gel Formulation. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.xphs.2018.05.004 en
pubs.issue 9 en
pubs.begin-page 2399 en
pubs.volume 107 en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 29777717 en
pubs.end-page 2403 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 741306 en Medical and Health Sciences en Pharmacy en School of Medicine en Surgery Department en
dc.identifier.eissn 1520-6017 en
pubs.record-created-at-source-date 2018-05-20 en
pubs.dimensions-id 29777717 en

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