Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade.

Show simple item record Mountjoy, Kathleen en 2020-02-13T03:00:21Z en 2015-06 en
dc.identifier.citation J Neuroendocrinol, 2015 en
dc.identifier.issn 0953-8194 en
dc.identifier.uri en
dc.description.abstract Following the cloning of the melanocortin receptor and agouti protein genes, a model was developed for the central melanocortin system with respect to the regulation of energy and glucose homeostasis. This model comprised leptin regulation of melanocortin peptides and agouti-related peptide (AgRP) produced from central pro-opiomelanocortin (POMC) and AgRP neurones, respectively, as well as AgRP competitive antagonism of melanocortin peptides activating melanocortin 4 receptor (MC4R) to Gαs and the cAMP signalling pathway. In the last decade, there have been paradigm shifts in our understanding of the central melanocortin system as a result of the application of advanced new technologies, including Cre-LoxP transgenic mouse technology, pharmacogenetics and optogenetics. During this period, our understanding of G protein coupled receptor signal transduction has also dramatically changed, such that these receptors are now known to exist in the plasma membrane oscillating between various inactive and active conformational states, and the active states signal through G protein-dependent and G protein-independent pathways. The present review focuses on evidence obtained over the past decade that has changed our understanding of POMC gene expression and regulation in the central nervous system, POMC and AgRP neuronal circuitry, neuroanatomical functions of melanocortin receptors, melanocortin 3 receptor (MC3R) and MC4R, and signal transduction through MC3R and MC4R. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries Journal of neuroendocrinology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Neurons en
dc.subject Animals en
dc.subject Humans en
dc.subject Obesity en
dc.subject Pro-Opiomelanocortin en
dc.subject Peptides en
dc.subject Receptors, Melanocortin en
dc.subject Feeding Behavior en
dc.title Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade. en
dc.type Journal Article en
dc.identifier.doi 10.1111/jne.12285 en
pubs.issue 6 en
pubs.begin-page 406 en
pubs.volume 27 en
dc.identifier.pmid 25872650 en
pubs.end-page 418 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 486561 en Medical and Health Sciences en Medical Sciences en Physiology Division en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1365-2826 en
pubs.record-created-at-source-date 2015-05-27 en
pubs.dimensions-id 25872650 en

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