dc.contributor.author |
Bansal, Mahima |
en |
dc.contributor.author |
Sharma, Manisha |
en |
dc.contributor.author |
Bullen, Christopher |
en |
dc.contributor.author |
Svirskis, Darren |
en |
dc.date.accessioned |
2020-02-13T21:13:52Z |
en |
dc.date.issued |
2018-08-13 |
en |
dc.identifier.citation |
International journal of environmental research and public health 15(8) 13 Aug 2018 |
en |
dc.identifier.issn |
1661-7827 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/50012 |
en |
dc.description.abstract |
(1) Background: Despite the growing use of e-cigarettes, in most countries, there is no regulation covering manufacturing standards of the solution ('e-liquid'), leading to concerns over the accuracy of labelling and stability of the products under a range of conditions. Following the United States (US) Food and Drug Administration (FDA) requirements for manufacture of e-liquids, we aimed to develop a simple high-performance liquid chromatography (HPLC) method to determine nicotine content in nicotine-containing e-liquids, even in the presence of degradation products; (2) Methods: We developed an HPLC method to quantify nicotine in the presence of the two major constituents of all e-liquids, glycerine and propylene glycol, and in the presence of degradation products; (3) Results: Our HPLC method performed strongly and was validated it according to international guidelines. For the e-liquids tested, nicotine content levels were all higher than labelled (up to 117.9 ± 1.87% of the labelled content). While nicotine was shown to be unstable at 60 °C, it was stabilized at this temperature in the e-liquid formulations for up to 10 days; and (4) Conclusions: The HPLC method is suitable for adoption by laboratories to determine the actual content and stability of nicotine-containing products. The higher than labelled nicotine levels in e-liquids raises clinical and public health concerns. |
en |
dc.format.medium |
Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
International journal of environmental research and public health |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Humans |
en |
dc.subject |
Propylene Glycol |
en |
dc.subject |
Glycerol |
en |
dc.subject |
Nicotine |
en |
dc.subject |
Chromatography, High Pressure Liquid |
en |
dc.subject |
Reproducibility of Results |
en |
dc.subject |
Commerce |
en |
dc.subject |
Product Labeling |
en |
dc.subject |
Electronic Nicotine Delivery Systems |
en |
dc.title |
A Stability Indicating HPLC Method to Determine Actual Content and Stability of Nicotine within Electronic Cigarette Liquids. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3390/ijerph15081737 |
en |
pubs.issue |
8 |
en |
pubs.volume |
15 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
research-article |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
751878 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Pharmacy |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Pacific Health |
en |
dc.identifier.eissn |
1660-4601 |
en |
pubs.record-created-at-source-date |
2018-08-15 |
en |
pubs.dimensions-id |
30104538 |
en |