A Stability Indicating HPLC Method to Determine Actual Content and Stability of Nicotine within Electronic Cigarette Liquids.

Show simple item record

dc.contributor.author Bansal, Mahima en
dc.contributor.author Sharma, Manisha en
dc.contributor.author Bullen, Christopher en
dc.contributor.author Svirskis, Darren en
dc.date.accessioned 2020-02-13T21:13:52Z en
dc.date.issued 2018-08-13 en
dc.identifier.citation International journal of environmental research and public health 15(8) 13 Aug 2018 en
dc.identifier.issn 1661-7827 en
dc.identifier.uri http://hdl.handle.net/2292/50012 en
dc.description.abstract (1) Background: Despite the growing use of e-cigarettes, in most countries, there is no regulation covering manufacturing standards of the solution ('e-liquid'), leading to concerns over the accuracy of labelling and stability of the products under a range of conditions. Following the United States (US) Food and Drug Administration (FDA) requirements for manufacture of e-liquids, we aimed to develop a simple high-performance liquid chromatography (HPLC) method to determine nicotine content in nicotine-containing e-liquids, even in the presence of degradation products; (2) Methods: We developed an HPLC method to quantify nicotine in the presence of the two major constituents of all e-liquids, glycerine and propylene glycol, and in the presence of degradation products; (3) Results: Our HPLC method performed strongly and was validated it according to international guidelines. For the e-liquids tested, nicotine content levels were all higher than labelled (up to 117.9 ± 1.87% of the labelled content). While nicotine was shown to be unstable at 60 °C, it was stabilized at this temperature in the e-liquid formulations for up to 10 days; and (4) Conclusions: The HPLC method is suitable for adoption by laboratories to determine the actual content and stability of nicotine-containing products. The higher than labelled nicotine levels in e-liquids raises clinical and public health concerns. en
dc.format.medium Electronic en
dc.language eng en
dc.relation.ispartofseries International journal of environmental research and public health en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Humans en
dc.subject Propylene Glycol en
dc.subject Glycerol en
dc.subject Nicotine en
dc.subject Chromatography, High Pressure Liquid en
dc.subject Reproducibility of Results en
dc.subject Commerce en
dc.subject Product Labeling en
dc.subject Electronic Nicotine Delivery Systems en
dc.title A Stability Indicating HPLC Method to Determine Actual Content and Stability of Nicotine within Electronic Cigarette Liquids. en
dc.type Journal Article en
dc.identifier.doi 10.3390/ijerph15081737 en
pubs.issue 8 en
pubs.volume 15 en
dc.rights.holder Copyright: The authors en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype research-article en
pubs.subtype Journal Article en
pubs.elements-id 751878 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
pubs.org-id Population Health en
pubs.org-id Pacific Health en
dc.identifier.eissn 1660-4601 en
pubs.record-created-at-source-date 2018-08-15 en
pubs.dimensions-id 30104538 en

Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace