Determining Neurotrophin Gradients in Vitro To Direct Axonal Outgrowth Following Spinal Cord Injury.

Show simple item record Dravid, Anusha en Parittotokkaporn, Sam en Aqrawe, Zaid en OCarroll, Simon en Svirskis, Darren en 2020-02-14T03:00:22Z en 2020-01 en
dc.identifier.issn 1948-7193 en
dc.identifier.uri en
dc.description.abstract A spinal cord injury can damage neuronal connections required for both motor and sensory function. Barriers to regeneration within the central nervous system, including an absence of neurotrophic stimulation, impair the ability of injured neurons to reestablish their original circuitry. Exogenous neurotrophin administration has been shown to promote axonal regeneration and outgrowth following injury. The neurotrophins possess chemotrophic properties that guide axons toward the region of highest concentration. These growth factors have demonstrated potential to be used as a therapeutic intervention for orienting axonal growth beyond the injury lesion, toward denervated targets. However, the success of this approach is dependent on the appropriate spatiotemporal distribution of these molecules to ensure detection and navigation by the axonal growth cone. A number of in vitro gradient-based assays have been employed to investigate axonal response to neurotrophic gradients. Such platforms have helped elucidate the potential of applying a concentration gradient of neurotrophins to promote directed axonal regeneration toward a functionally significant target. Here, we review these techniques and the principles of gradient detection in axonal guidance, with particular focus on the use of neurotrophins to orient the trajectory of regenerating axons. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries ACS chemical neuroscience en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Determining Neurotrophin Gradients in Vitro To Direct Axonal Outgrowth Following Spinal Cord Injury. en
dc.type Journal Article en
dc.identifier.doi 10.1021/acschemneuro.9b00565 en
pubs.issue 2 en
pubs.begin-page 121 en
pubs.volume 11 en
dc.rights.holder Copyright: The author en
pubs.end-page 132 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Journal Article en
pubs.elements-id 790675 en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en Pharmacy en
dc.identifier.eissn 1948-7193 en
pubs.record-created-at-source-date 2019-12-12 en
pubs.dimensions-id 31825204 en

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