dc.contributor.author |
Harris, Deborah |
en |
dc.contributor.author |
Weston, Philip J |
en |
dc.contributor.author |
Harding, Jane |
en |
dc.date.accessioned |
2020-02-14T03:26:18Z |
en |
dc.date.issued |
2019-09 |
en |
dc.identifier.issn |
1359-2998 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/50041 |
en |
dc.description.abstract |
OBJECTIVE:Babies may use alternative cerebral fuels including ketones when blood glucose concentrations are low, but laboratory ketone measurements are slow and expensive. Point-of-care measurement of ketone concentrations, if sufficiently accurate, may provide useful information for clinical care. PATIENTS AND DESIGN:Eligible babies were 35-42 weeks' gestation, ≤10 days old and admitted to the newborn intensive care unit. At the time of clinically indicated blood tests, additional samples were taken to measure beta-hydroxybutyrate using a point-of-care analyser and the laboratory method. RESULTS:One-hundred and fifty babies had 142 paired samples. Overall point-of-care accuracy was excellent (mean difference 0.00 mmol/L) and precision was moderate (SD 0.18 mmol/L). A point-of-care measurement ≥0.4 mmol/L was highly predictive of a laboratory measurement ≥0.4 mmol/L (area under the curve 0.98). CONCLUSION:Point-of-care measurement of blood beta-hydroxybutyrate concentrations is sufficiently accurate in newborns to be potentially useful in clinical care. CLINICAL TRIAL REGISTRATION NUMBER:Registered with the Australian and New Zealand Clinical Trials Registry ACTRN: 12616000784415. The study was registered before recruitment commenced. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Archives of disease in childhood. Fetal and neonatal edition |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Hypoglycemia |
en |
dc.subject |
3-Hydroxybutyric Acid |
en |
dc.subject |
Neonatal Screening |
en |
dc.subject |
Reproducibility of Results |
en |
dc.subject |
Gestational Age |
en |
dc.subject |
Infant, Newborn |
en |
dc.subject |
Intensive Care Units, Neonatal |
en |
dc.subject |
Point-of-Care Systems |
en |
dc.subject |
New Zealand |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Dimensional Measurement Accuracy |
en |
dc.title |
Point-of-care measurements of blood ketones in newborns. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1136/archdischild-2018-316293 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
F544 |
en |
pubs.volume |
104 |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.end-page |
F546 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
756087 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
LiFePATH |
en |
dc.identifier.eissn |
1468-2052 |
en |
pubs.record-created-at-source-date |
2018-11-03 |
en |
pubs.dimensions-id |
30385513 |
en |