Objectively Assessed Foot and Ankle Characteristics in Patients With Systemic Lupus Erythematosus: A Comparison With Age- and Sex-Matched Controls.

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dc.contributor.author Stewart, Sarah en
dc.contributor.author Dalbeth, Nicola en
dc.contributor.author Aiyer, Ash en
dc.contributor.author Rome, Keith en
dc.date.accessioned 2020-02-14T03:37:58Z en
dc.date.issued 2020-01 en
dc.identifier.issn 2151-464X en
dc.identifier.uri http://hdl.handle.net/2292/50042 en
dc.description.abstract OBJECTIVE:To objectively identify foot and ankle characteristics in patients with systemic lupus erythematosus (SLE) compared to age- and sex-matched controls. METHODS:A total of 54 patients with SLE and 56 control participants attended a study visit designed to comprehensively assess the foot and ankle. Objectively assessed foot characteristics included muscle strength, joint motion, foot posture, foot problems, protective sensation, vibration perception threshold (VPT), ankle brachial index (ABI), plantar pressure, and spatiotemporal gait characteristics. Self-reported measure of foot pain and impairment were also assessed using a 100-mm foot pain visual analog scale. Data were analyzed using regression models. Plantar pressure and gait models were adjusted for walking velocity, body mass index, and foot pain. RESULTS:Compared to controls, participants with SLE had lower muscle force for plantarflexion, dorsiflexion, inversion, and eversion (all P < 0.001), higher foot posture indices (P = 0.007), higher foot problem scores (P = 0.001), higher VPT (P = 0.001), and more frequent abnormal ABI (odds ratio [OR] 3.13, P = 0.044). Participants with SLE also had lower peak pressure and higher pressure time integrals for all foot regions (all P < 0.001), lower step and stride length, velocity, and cadence, and higher step, swing, stance, and single and double support times compared to controls (all P < 0.001). Compared to controls, participants with SLE also reported greater foot pain (P < 0.001). CONCLUSION:Patients with SLE experience a wide range of foot symptoms. This study has provided objective evidence of foot and ankle disease in patients with SLE, including reduced muscle strength and altered gait patterns when compared to controls. This highlights the importance of foot health assessments as part of SLE management. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Arthritis care & research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Muscle, Skeletal en
dc.subject Foot Joints en
dc.subject Ankle Joint en
dc.subject Humans en
dc.subject Joint Diseases en
dc.subject Lupus Erythematosus, Systemic en
dc.subject Gait en
dc.subject Walking en
dc.subject Cross-Sectional Studies en
dc.subject Middle Aged en
dc.subject Female en
dc.subject Male en
dc.subject Muscle Strength en
dc.subject Biomechanical Phenomena en
dc.title Objectively Assessed Foot and Ankle Characteristics in Patients With Systemic Lupus Erythematosus: A Comparison With Age- and Sex-Matched Controls. en
dc.type Journal Article en
dc.identifier.doi 10.1002/acr.23832 en
pubs.issue 1 en
pubs.begin-page 122 en
pubs.volume 72 en
dc.rights.holder Copyright: The author en
pubs.end-page 130 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Multicenter Study en
pubs.subtype Journal Article en
pubs.subtype Observational Study en
pubs.elements-id 790207 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.eissn 2151-4658 en
pubs.record-created-at-source-date 2019-01-11 en
pubs.dimensions-id 30629828 en

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