Human placenta and trophoblast development: key molecular mechanisms and model systems.

Show simple item record Knöfler, Martin en Haider, Sandra en Saleh, Leila en Pollheimer, Jürgen en Gamage, Teena en James, Joanna en 2020-02-14T03:47:53Z en 2019-09 en
dc.identifier.citation Cellular and molecular life sciences : CMLS 76(18):3479-3496 Sep 2019 en
dc.identifier.issn 1420-682X en
dc.identifier.uri en
dc.description.abstract Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such as cardiovascular disease and type 2 diabetes. Despite their importance, the molecular mechanisms governing human placental formation and trophoblast cell lineage specification and differentiation have been poorly unravelled, mostly due to the lack of appropriate cellular model systems. However, over the past few years major progress has been made by establishing self-renewing human trophoblast stem cells and 3-dimensional organoids from human blastocysts and early placental tissues opening the path for detailed molecular investigations. Herein, we summarize the present knowledge about human placental development, its stem cells, progenitors and differentiated cell types in the trophoblast epithelium and the villous core. Anatomy of the early placenta, current model systems, and critical key regulatory factors and signalling cascades governing placentation will be elucidated. In this context, we will discuss the role of the developmental pathways Wingless and Notch, controlling trophoblast stemness/differentiation and formation of invasive trophoblast progenitors, respectively. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Cellular and molecular life sciences : CMLS en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.rights.uri en
dc.subject Trophoblasts en
dc.subject Placenta en
dc.subject Humans en
dc.subject Cardiovascular Diseases en
dc.subject Diabetes Mellitus, Type 2 en
dc.subject Signal Transduction en
dc.subject Cell Differentiation en
dc.subject Pregnancy en
dc.subject Placentation en
dc.subject Models, Biological en
dc.subject Female en
dc.title Human placenta and trophoblast development: key molecular mechanisms and model systems. en
dc.type Journal Article en
dc.identifier.doi 10.1007/s00018-019-03104-6 en
pubs.issue 18 en
pubs.begin-page 3479 en
pubs.volume 76 en
dc.rights.holder Copyright: The authors en
pubs.end-page 3496 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype review-article en
pubs.subtype Review en
pubs.subtype Journal Article en
pubs.elements-id 772887 en Medical and Health Sciences en Medical Sciences en Physiology Division en School of Medicine en Obstetrics and Gynaecology en
dc.identifier.eissn 1420-9071 en
pubs.record-created-at-source-date 2019-05-04 en
pubs.dimensions-id 31049600 en

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