dc.contributor.author |
Knöfler, Martin |
en |
dc.contributor.author |
Haider, Sandra |
en |
dc.contributor.author |
Saleh, Leila |
en |
dc.contributor.author |
Pollheimer, Jürgen |
en |
dc.contributor.author |
Gamage, Teena |
en |
dc.contributor.author |
James, Joanna |
en |
dc.date.accessioned |
2020-02-14T03:47:53Z |
en |
dc.date.issued |
2019-09 |
en |
dc.identifier.citation |
Cellular and molecular life sciences : CMLS 76(18):3479-3496 Sep 2019 |
en |
dc.identifier.issn |
1420-682X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/50049 |
en |
dc.description.abstract |
Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such as cardiovascular disease and type 2 diabetes. Despite their importance, the molecular mechanisms governing human placental formation and trophoblast cell lineage specification and differentiation have been poorly unravelled, mostly due to the lack of appropriate cellular model systems. However, over the past few years major progress has been made by establishing self-renewing human trophoblast stem cells and 3-dimensional organoids from human blastocysts and early placental tissues opening the path for detailed molecular investigations. Herein, we summarize the present knowledge about human placental development, its stem cells, progenitors and differentiated cell types in the trophoblast epithelium and the villous core. Anatomy of the early placenta, current model systems, and critical key regulatory factors and signalling cascades governing placentation will be elucidated. In this context, we will discuss the role of the developmental pathways Wingless and Notch, controlling trophoblast stemness/differentiation and formation of invasive trophoblast progenitors, respectively. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Cellular and molecular life sciences : CMLS |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
en |
dc.subject |
Trophoblasts |
en |
dc.subject |
Placenta |
en |
dc.subject |
Humans |
en |
dc.subject |
Cardiovascular Diseases |
en |
dc.subject |
Diabetes Mellitus, Type 2 |
en |
dc.subject |
Signal Transduction |
en |
dc.subject |
Cell Differentiation |
en |
dc.subject |
Pregnancy |
en |
dc.subject |
Placentation |
en |
dc.subject |
Models, Biological |
en |
dc.subject |
Female |
en |
dc.title |
Human placenta and trophoblast development: key molecular mechanisms and model systems. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00018-019-03104-6 |
en |
pubs.issue |
18 |
en |
pubs.begin-page |
3479 |
en |
pubs.volume |
76 |
en |
dc.rights.holder |
Copyright: The authors |
en |
pubs.end-page |
3496 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
review-article |
en |
pubs.subtype |
Review |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
772887 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1420-9071 |
en |
pubs.record-created-at-source-date |
2019-05-04 |
en |
pubs.dimensions-id |
31049600 |
en |