Ex vivo evaluation of the stability, safety and antibacterial efficacy of an extemporaneous povidone-iodine preparation for ophthalmic applications.

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dc.contributor.author Lee, Stephen en
dc.contributor.author Khun, Darina en
dc.contributor.author Kumarasinghe, Gamith L en
dc.contributor.author De Zoysa, Gayan en
dc.contributor.author Sarojini Amma, Vijayalekshmi en
dc.contributor.author Vellara, Hans R en
dc.contributor.author Rupenthal, Ilva en
dc.contributor.author Thakur, Sachin en
dc.date.accessioned 2020-02-14T03:50:52Z en
dc.date.issued 2019-11 en
dc.identifier.issn 0816-4622 en
dc.identifier.uri http://hdl.handle.net/2292/50051 en
dc.description.abstract BACKGROUND:Povidone-iodine is used as a cost-effective broad-spectrum antiseptic in the prophylaxis and treatment of certain ocular infections. In this study, the stability, ophthalmic irritation potential and antibacterial efficacy of an extemporaneous povidone-iodine preparation was determined using established ex vivo and in vitro assays. METHODS:Extemporaneous iodine was prepared by simple dilution in normal saline. Preparation stability was evaluated by monitoring concentration and pH. Ocular safety was determined using the bovine cornea opacity and permeability assay. Efficacy was assessed by determining the minimum inhibitory and minimum bactericidal concentration of the preparation on Staphylococcus aureus and Pseudomonas aeruginosa. RESULTS:Diluted povidone-iodine maintained its stability over the 28-day evaluation. The formulation caused mild ocular irritation at the lowest prepared concentration (0.5 per cent w/v), with irritation noticeably increased at higher concentrations. The preparation showed minimum bactericidal and inhibitory concentrations of 0.078 and 0.3 per cent w/v on S. aureus and P. aeruginosa, respectively. CONCLUSIONS:This study confirms the stability and broad-spectrum antibacterial efficacy of povidone-iodine, while addressing the ocular irritation potential of this chemical. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Clinical & experimental optometry en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Ex vivo evaluation of the stability, safety and antibacterial efficacy of an extemporaneous povidone-iodine preparation for ophthalmic applications. en
dc.type Journal Article en
dc.identifier.doi 10.1111/cxo.12899 en
pubs.issue 6 en
pubs.begin-page 583 en
pubs.volume 102 en
dc.rights.holder Copyright: The author en
pubs.end-page 589 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.elements-id 767349 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
pubs.org-id School of Medicine en
pubs.org-id Ophthalmology Department en
pubs.org-id Science en
pubs.org-id Chemistry en
dc.identifier.eissn 1444-0938 en
pubs.record-created-at-source-date 2019-03-30 en
pubs.dimensions-id 30924199 en

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